Blood longitudinal (T 1) and transverse (T 2) relaxation time constants at 11.7 Tesla

Ai Ling Lin; Qin Qin; Xia Zhao; Timothy Q. Duong

doi:10.1007/s10334-011-0287-2

Blood longitudinal (T ₁) and transverse (T ₂) relaxation time constants at 11.7 Tesla

Ai Ling Lin
, Qin Qin
, Xia Zhao
, Timothy Q. Duong

Pharmacology and Nutritional Sciences

Producción científica: Article › revisión exhaustiva

50 Citas (Scopus)

Resumen

Object: The goal of the study was to determine blood T ₁ and T ₂ values as functions of oxygen saturation (Y), temperature (Temp) and hematocrit (Hct) at an ultrahigh MR field (11.7 T) and explore their impacts on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation determination. Materials and methods: T ₁ and T ₂ were simultaneously measured. Temperature was adjusted from 25 to 40°C to determine Temp dependence; Hct of 0.17-0.51 to evaluate Hct dependence at 25 and 37°C; and Y of 40-100% to evaluate Y dependence at 25 and 37°C. Comparisons were made with published data obtained at different magnetic field strengths (B ₀). Results: T ₁ was positively correlated with Temp, independent of Y, and negatively correlated with Hct. T ₂ was negatively correlated with Temp and Hct, but positively correlated with Y, in a non-linear fashion. T ₁ increased linearly with B ₀, whereas T ₂ decreased exponentially with B ₀. Conclusion: This study reported blood T ₁ and T ₂ measurements at 11.7 T for the first time. These blood relaxation data could have implications in numerous functional and physiological MRI studies at 11.7 T.

Idioma original	English
Páginas (desde-hasta)	245-249
Número de páginas	5
Publicación	Magnetic Resonance Materials in Physics, Biology and Medicine
Volumen	25
N.º	3
DOI	https://doi.org/10.1007/s10334-011-0287-2
Estado	Published - jun 2012

Nota bibliográfica

Funding Information:
We thank Hsiao-Ying Wey of the Research Imaging Institute and Saaussan Madi of Bruker Biospin for technical support. This work was supported by in part by the NIH (R01EY014211, R01EY018855) and VA MERIT. We are also grateful for the resources and support from NIH/NCRR (S10 RR023038), from the Defense Advanced Research Projects Agency (Comprehensive Facility for Animal Imaging Research (CFAIR), HR0011-07-C-0027), and the Texas Emerging Technology Fund from the Office of the Governor of Texas.

Financiación

We thank Hsiao-Ying Wey of the Research Imaging Institute and Saaussan Madi of Bruker Biospin for technical support. This work was supported by in part by the NIH (R01EY014211, R01EY018855) and VA MERIT. We are also grateful for the resources and support from NIH/NCRR (S10 RR023038), from the Defense Advanced Research Projects Agency (Comprehensive Facility for Animal Imaging Research (CFAIR), HR0011-07-C-0027), and the Texas Emerging Technology Fund from the Office of the Governor of Texas.

Financiadores	Número del financiador
CFAIR	HR0011-07-C-0027
Comprehensive Facility for Animal Imaging Research
Office of the Governor of Texas
VA Merit Award
National Institutes of Health (NIH)	R01EY014211
National Institutes of Health (NIH)
National Eye Institute/National Institutes of Health	R01EY018855
National Eye Institute/National Institutes of Health
National Center for Research Resources	S10 RR023038
National Center for Research Resources
Defense Advanced Research Projects Agency
Texas Emerging Technology Fund

ASJC Scopus subject areas

Biophysics
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Acceder al documento

10.1007/s10334-011-0287-2

Otros archivos y enlaces

Citar esto

@article{0573c2b319d44a7ba6386f7181fadbae,

title = "Blood longitudinal (T 1) and transverse (T 2) relaxation time constants at 11.7 Tesla",

abstract = "Object: The goal of the study was to determine blood T 1 and T 2 values as functions of oxygen saturation (Y), temperature (Temp) and hematocrit (Hct) at an ultrahigh MR field (11.7 T) and explore their impacts on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation determination. Materials and methods: T 1 and T 2 were simultaneously measured. Temperature was adjusted from 25 to 40°C to determine Temp dependence; Hct of 0.17-0.51 to evaluate Hct dependence at 25 and 37°C; and Y of 40-100\% to evaluate Y dependence at 25 and 37°C. Comparisons were made with published data obtained at different magnetic field strengths (B 0). Results: T 1 was positively correlated with Temp, independent of Y, and negatively correlated with Hct. T 2 was negatively correlated with Temp and Hct, but positively correlated with Y, in a non-linear fashion. T 1 increased linearly with B 0, whereas T 2 decreased exponentially with B 0. Conclusion: This study reported blood T 1 and T 2 measurements at 11.7 T for the first time. These blood relaxation data could have implications in numerous functional and physiological MRI studies at 11.7 T.",

keywords = "ASL, BOLD fMRI, High fields, TRUST, VASO",

author = "Lin, \{Ai Ling\} and Qin Qin and Xia Zhao and Duong, \{Timothy Q.\}",

note = "Funding Information: We thank Hsiao-Ying Wey of the Research Imaging Institute and Saaussan Madi of Bruker Biospin for technical support. This work was supported by in part by the NIH (R01EY014211, R01EY018855) and VA MERIT. We are also grateful for the resources and support from NIH/NCRR (S10 RR023038), from the Defense Advanced Research Projects Agency (Comprehensive Facility for Animal Imaging Research (CFAIR), HR0011-07-C-0027), and the Texas Emerging Technology Fund from the Office of the Governor of Texas.",

year = "2012",

month = jun,

doi = "10.1007/s10334-011-0287-2",

language = "English",

volume = "25",

pages = "245--249",

number = "3",

}

TY - JOUR

T1 - Blood longitudinal (T 1) and transverse (T 2) relaxation time constants at 11.7 Tesla

AU - Lin, Ai Ling

AU - Qin, Qin

AU - Zhao, Xia

AU - Duong, Timothy Q.

N1 - Funding Information: We thank Hsiao-Ying Wey of the Research Imaging Institute and Saaussan Madi of Bruker Biospin for technical support. This work was supported by in part by the NIH (R01EY014211, R01EY018855) and VA MERIT. We are also grateful for the resources and support from NIH/NCRR (S10 RR023038), from the Defense Advanced Research Projects Agency (Comprehensive Facility for Animal Imaging Research (CFAIR), HR0011-07-C-0027), and the Texas Emerging Technology Fund from the Office of the Governor of Texas.

PY - 2012/6

Y1 - 2012/6

N2 - Object: The goal of the study was to determine blood T 1 and T 2 values as functions of oxygen saturation (Y), temperature (Temp) and hematocrit (Hct) at an ultrahigh MR field (11.7 T) and explore their impacts on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation determination. Materials and methods: T 1 and T 2 were simultaneously measured. Temperature was adjusted from 25 to 40°C to determine Temp dependence; Hct of 0.17-0.51 to evaluate Hct dependence at 25 and 37°C; and Y of 40-100% to evaluate Y dependence at 25 and 37°C. Comparisons were made with published data obtained at different magnetic field strengths (B 0). Results: T 1 was positively correlated with Temp, independent of Y, and negatively correlated with Hct. T 2 was negatively correlated with Temp and Hct, but positively correlated with Y, in a non-linear fashion. T 1 increased linearly with B 0, whereas T 2 decreased exponentially with B 0. Conclusion: This study reported blood T 1 and T 2 measurements at 11.7 T for the first time. These blood relaxation data could have implications in numerous functional and physiological MRI studies at 11.7 T.

AB - Object: The goal of the study was to determine blood T 1 and T 2 values as functions of oxygen saturation (Y), temperature (Temp) and hematocrit (Hct) at an ultrahigh MR field (11.7 T) and explore their impacts on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation determination. Materials and methods: T 1 and T 2 were simultaneously measured. Temperature was adjusted from 25 to 40°C to determine Temp dependence; Hct of 0.17-0.51 to evaluate Hct dependence at 25 and 37°C; and Y of 40-100% to evaluate Y dependence at 25 and 37°C. Comparisons were made with published data obtained at different magnetic field strengths (B 0). Results: T 1 was positively correlated with Temp, independent of Y, and negatively correlated with Hct. T 2 was negatively correlated with Temp and Hct, but positively correlated with Y, in a non-linear fashion. T 1 increased linearly with B 0, whereas T 2 decreased exponentially with B 0. Conclusion: This study reported blood T 1 and T 2 measurements at 11.7 T for the first time. These blood relaxation data could have implications in numerous functional and physiological MRI studies at 11.7 T.

KW - ASL

KW - BOLD fMRI

KW - High fields

KW - TRUST

KW - VASO

UR - https://www.scopus.com/pages/publications/84862013419

UR - https://www.scopus.com/pages/publications/84862013419#tab=citedBy

U2 - 10.1007/s10334-011-0287-2

DO - 10.1007/s10334-011-0287-2

M3 - Article

C2 - 22071580

AN - SCOPUS:84862013419

SN - 0968-5243

VL - 25

SP - 245

EP - 249

JO - Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magnetic Resonance Materials in Physics, Biology and Medicine

IS - 3

ER -