Brain catecholamine content during the estrous cycle and in steroid-primed rats

Kenneth J. Renner; Greg A. Gerhardt; David M. Quadagno

doi:10.1016/0361-9230(84)90105-9

Brain catecholamine content during the estrous cycle and in steroid-primed rats

Kenneth J. Renner
, Greg A. Gerhardt
, David M. Quadagno

Producción científica: Article › revisión exhaustiva

14 Citas (Scopus)

Resumen

Norepinephrine (NE) and dopamine (DA) levels were measured in several estrogen concentrating brain regions over the estrous cycle and in steroid-primed ovariectomized rats under experimental conditions used to study sexual receptivity. Norepinephrine content in the ventromedial hypothalamus (VMH), lateral septum (LS) and medial preoptic area (POA) varied during the estrous cycle. The highest NE levels were found during metestrus in these brain regions. In the ovariectomized rat, NE levels were increased in the POA and LS 12 hours (hr) after the injection of 3 μg of estradiol benzoate (65% and 33%, respectively). Norepinephrine content in the POA and LS remained elevated 24 hr and 48 hr (0.5 mg progesterone at 42 hr) after treatment but were not different from control levels at 96 hr. Dopamine concentrations were not significantly altered over the estrous cycle or by the administration of estradiol benzoate in any of the brain regions studied. These results suggest that estrogen may selectively alter noradrenergic activity in brain regions that are implicated in the control of sexual receptivity and/or ovulation.

Idioma original	English
Páginas (desde-hasta)	363-368
Número de páginas	6
Publicación	Brain Research Bulletin
Volumen	12
N.º	4
DOI	https://doi.org/10.1016/0361-9230(84)90105-9
Estado	Published - abr 1984

Nota bibliográfica

Funding Information:
This research was supported by NlCHHD grant HDI 1103 and G.A.G. received financial support from NSF Grant BNS 7914226. We wish to thank Dr. Ralph Adams and the members of his laboratory, Charles Bradberry, Rick Hart, Ramilla Lewis, Kirk Mills, Dr. Arvin Oke and Margaret Rice for supplying the technical expertise, advice and equipment for the measurement of the catecholamines. We also wish to thank Dr. Victoria Luine for her helpful advice and discussions during the writing of this paper, Dr. Joseph Bast for help and advice, Ms. Fran Williams and Coletta Spencer for excellent word processing assistance, and Sharon Hagen for her fine graphics.

Financiación

This research was supported by NlCHHD grant HDI 1103 and G.A.G. received financial support from NSF Grant BNS 7914226. We wish to thank Dr. Ralph Adams and the members of his laboratory, Charles Bradberry, Rick Hart, Ramilla Lewis, Kirk Mills, Dr. Arvin Oke and Margaret Rice for supplying the technical expertise, advice and equipment for the measurement of the catecholamines. We also wish to thank Dr. Victoria Luine for her helpful advice and discussions during the writing of this paper, Dr. Joseph Bast for help and advice, Ms. Fran Williams and Coletta Spencer for excellent word processing assistance, and Sharon Hagen for her fine graphics.

Financiadores	Número del financiador
NlCHHD	HDI 1103
National Science Foundation (NSF)	BNS 7914226

ASJC Scopus subject areas

General Neuroscience

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10.1016/0361-9230(84)90105-9

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title = "Brain catecholamine content during the estrous cycle and in steroid-primed rats",

abstract = "Norepinephrine (NE) and dopamine (DA) levels were measured in several estrogen concentrating brain regions over the estrous cycle and in steroid-primed ovariectomized rats under experimental conditions used to study sexual receptivity. Norepinephrine content in the ventromedial hypothalamus (VMH), lateral septum (LS) and medial preoptic area (POA) varied during the estrous cycle. The highest NE levels were found during metestrus in these brain regions. In the ovariectomized rat, NE levels were increased in the POA and LS 12 hours (hr) after the injection of 3 μg of estradiol benzoate (65\% and 33\%, respectively). Norepinephrine content in the POA and LS remained elevated 24 hr and 48 hr (0.5 mg progesterone at 42 hr) after treatment but were not different from control levels at 96 hr. Dopamine concentrations were not significantly altered over the estrous cycle or by the administration of estradiol benzoate in any of the brain regions studied. These results suggest that estrogen may selectively alter noradrenergic activity in brain regions that are implicated in the control of sexual receptivity and/or ovulation.",

keywords = "Amygdala, Estrous cycle, Hypothalamus, Lateral septum, Lordosis behavior, Norepinephrine",

author = "Renner, \{Kenneth J.\} and Gerhardt, \{Greg A.\} and Quadagno, \{David M.\}",

note = "Funding Information: This research was supported by NlCHHD grant HDI 1103 and G.A.G. received financial support from NSF Grant BNS 7914226. We wish to thank Dr. Ralph Adams and the members of his laboratory, Charles Bradberry, Rick Hart, Ramilla Lewis, Kirk Mills, Dr. Arvin Oke and Margaret Rice for supplying the technical expertise, advice and equipment for the measurement of the catecholamines. We also wish to thank Dr. Victoria Luine for her helpful advice and discussions during the writing of this paper, Dr. Joseph Bast for help and advice, Ms. Fran Williams and Coletta Spencer for excellent word processing assistance, and Sharon Hagen for her fine graphics.",

year = "1984",

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AU - Gerhardt, Greg A.

AU - Quadagno, David M.

N1 - Funding Information: This research was supported by NlCHHD grant HDI 1103 and G.A.G. received financial support from NSF Grant BNS 7914226. We wish to thank Dr. Ralph Adams and the members of his laboratory, Charles Bradberry, Rick Hart, Ramilla Lewis, Kirk Mills, Dr. Arvin Oke and Margaret Rice for supplying the technical expertise, advice and equipment for the measurement of the catecholamines. We also wish to thank Dr. Victoria Luine for her helpful advice and discussions during the writing of this paper, Dr. Joseph Bast for help and advice, Ms. Fran Williams and Coletta Spencer for excellent word processing assistance, and Sharon Hagen for her fine graphics.

PY - 1984/4

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N2 - Norepinephrine (NE) and dopamine (DA) levels were measured in several estrogen concentrating brain regions over the estrous cycle and in steroid-primed ovariectomized rats under experimental conditions used to study sexual receptivity. Norepinephrine content in the ventromedial hypothalamus (VMH), lateral septum (LS) and medial preoptic area (POA) varied during the estrous cycle. The highest NE levels were found during metestrus in these brain regions. In the ovariectomized rat, NE levels were increased in the POA and LS 12 hours (hr) after the injection of 3 μg of estradiol benzoate (65% and 33%, respectively). Norepinephrine content in the POA and LS remained elevated 24 hr and 48 hr (0.5 mg progesterone at 42 hr) after treatment but were not different from control levels at 96 hr. Dopamine concentrations were not significantly altered over the estrous cycle or by the administration of estradiol benzoate in any of the brain regions studied. These results suggest that estrogen may selectively alter noradrenergic activity in brain regions that are implicated in the control of sexual receptivity and/or ovulation.

AB - Norepinephrine (NE) and dopamine (DA) levels were measured in several estrogen concentrating brain regions over the estrous cycle and in steroid-primed ovariectomized rats under experimental conditions used to study sexual receptivity. Norepinephrine content in the ventromedial hypothalamus (VMH), lateral septum (LS) and medial preoptic area (POA) varied during the estrous cycle. The highest NE levels were found during metestrus in these brain regions. In the ovariectomized rat, NE levels were increased in the POA and LS 12 hours (hr) after the injection of 3 μg of estradiol benzoate (65% and 33%, respectively). Norepinephrine content in the POA and LS remained elevated 24 hr and 48 hr (0.5 mg progesterone at 42 hr) after treatment but were not different from control levels at 96 hr. Dopamine concentrations were not significantly altered over the estrous cycle or by the administration of estradiol benzoate in any of the brain regions studied. These results suggest that estrogen may selectively alter noradrenergic activity in brain regions that are implicated in the control of sexual receptivity and/or ovulation.

KW - Amygdala

KW - Estrous cycle

KW - Hypothalamus

KW - Lateral septum

KW - Lordosis behavior

KW - Norepinephrine

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SN - 0361-9230

VL - 12

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EP - 368

JO - Brain Research Bulletin

JF - Brain Research Bulletin

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ER -

Brain catecholamine content during the estrous cycle and in steroid-primed rats

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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