Brief Historical Overview on the Use of Animals in Research

The relationship between animals and man has evolved over several millennia and it is now recognized that a multitude of biological similarities allow us to use animals as models to better understand basic biological, physiological, and pathological processes with import to both human and animal health. A great deal has been learned from animals that spontaneously develop disease, as well as from new models that have been genetically manipulated. An appreciation for the importance to control animal care variables that might affect the integrity of research, as well as a desire to optimize animal health and wellbeing has led to development of standards for animal care and evolution in approaches to ensuring a sound environment for animal maintenance.