C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

Louise Bitting; Ellen L. Sutin; Fiona L. Watson; Lorriana E. Leard; Bruce F. O'Hara; H. Craig Heller; Thomas S. Kilduff

doi:10.1016/0304-3940(94)90723-4

C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

Louise Bitting
, Ellen L. Sutin
, Fiona L. Watson
, Lorriana E. Leard
, Bruce F. O'Hara
, H. Craig Heller
, Thomas S. Kilduff

Biology

Producción científica: Article › revisión exhaustiva

39 Citas (Scopus)

Resumen

During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.

Idioma original	English
Páginas (desde-hasta)	117-121
Número de páginas	5
Publicación	Neuroscience Letters
Volumen	165
N.º	1-2
DOI	https://doi.org/10.1016/0304-3940(94)90723-4
Estado	Published - ene 3 1994

Nota bibliográfica

Funding Information:
Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.

Financiación

Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.

Financiadores	Número del financiador
National Institute for Health Research Biomedical Research Centre at South London and Maudsley National Health Service	AG05556
Upjohn Company
National Institute of Mental Health	T32MH017047
American Association of University Women

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(94)90723-4

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title = "C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation",

abstract = "During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.",

keywords = "Arousal, Circadian rhythm, Fos, Hypothalamus, Circannual rhythm, Transcriptional regulation",

author = "Louise Bitting and Sutin, \{Ellen L.\} and Watson, \{Fiona L.\} and Leard, \{Lorriana E.\} and O'Hara, \{Bruce F.\} and \{Craig Heller\}, H. and Kilduff, \{Thomas S.\}",

note = "Funding Information: Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.",

year = "1994",

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doi = "10.1016/0304-3940(94)90723-4",

language = "English",

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T1 - C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

AU - Bitting, Louise

AU - Sutin, Ellen L.

AU - Watson, Fiona L.

AU - Leard, Lorriana E.

AU - O'Hara, Bruce F.

AU - Craig Heller, H.

AU - Kilduff, Thomas S.

N1 - Funding Information: Research supported by National Institute of Health National Research Service Award AG05556 to E.L.S., National Institute of Health Pre-Doctoral Fellowship MH17047 and a Continuing Education Grant from the American Association of University Women to L.B., and a grant from the Upjohn Company. The authors would like to thank Julio Panta for excellent animal husbandry and assistance.

PY - 1994/1/3

Y1 - 1994/1/3

N2 - During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.

AB - During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5°C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.

KW - Arousal

KW - Circadian rhythm

KW - Fos

KW - Hypothalamus, Circannual rhythm

KW - Transcriptional regulation

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U2 - 10.1016/0304-3940(94)90723-4

DO - 10.1016/0304-3940(94)90723-4

M3 - Article

C2 - 8015710

AN - SCOPUS:0028123619

SN - 0304-3940

VL - 165

SP - 117

EP - 121

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

Resumen

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Financiación

ASJC Scopus subject areas

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