C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin

Susanna M. Rybak; David S. Auld; Daret K.St Clair; Qi Zhi Yao; James W. Fett

doi:10.1016/0006-291X(89)92030-5

C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin

Susanna M. Rybak
, David S. Auld
, Daret K.St Clair
, Qi Zhi Yao
, James W. Fett

Producción científica: Article › revisión exhaustiva

10 Citas (Scopus)

Resumen

Synthetic peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal peptides also inhibit nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.

Idioma original	English
Páginas (desde-hasta)	535-543
Número de páginas	9
Publicación	Biochemical and Biophysical Research Communications
Volumen	162
N.º	1
DOI	https://doi.org/10.1016/0006-291X(89)92030-5
Estado	Published - jul 14 1989

Nota bibliográfica

Funding Information:
We thank Dr. B.L. Vallee for continued advice and support, Dr. J.L. Bethune for statistical analysis of the CAM results, and Mr. Douglas S. Auld for assistance in preparing synthetic peptides. This work was supported by the Endowment for Research in Human Biology, Inc. and in part by funds from Hoechst, A.G. under agreements with Harvard University.

Financiación

We thank Dr. B.L. Vallee for continued advice and support, Dr. J.L. Bethune for statistical analysis of the CAM results, and Mr. Douglas S. Auld for assistance in preparing synthetic peptides. This work was supported by the Endowment for Research in Human Biology, Inc. and in part by funds from Hoechst, A.G. under agreements with Harvard University.

Financiadores
Endowment for Research in Human Biology, Inc.
Harvard University

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Acceder al documento

10.1016/0006-291X(89)92030-5

Otros archivos y enlaces

Citar esto

@article{458de5ec2456497ab6e2eb68e10ba4fa,

title = "C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin",

abstract = "Synthetic peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal peptides also inhibit nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.",

author = "Rybak, \{Susanna M.\} and Auld, \{David S.\} and Clair, \{Daret K.St\} and Yao, \{Qi Zhi\} and Fett, \{James W.\}",

note = "Funding Information: We thank Dr. B.L. Vallee for continued advice and support, Dr. J.L. Bethune for statistical analysis of the CAM results, and Mr. Douglas S. Auld for assistance in preparing synthetic peptides. This work was supported by the Endowment for Research in Human Biology, Inc. and in part by funds from Hoechst, A.G. under agreements with Harvard University.",

year = "1989",

month = jul,

day = "14",

doi = "10.1016/0006-291X(89)92030-5",

language = "English",

volume = "162",

pages = "535--543",

number = "1",

}

TY - JOUR

T1 - C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin

AU - Rybak, Susanna M.

AU - Auld, David S.

AU - Clair, Daret K.St

AU - Yao, Qi Zhi

AU - Fett, James W.

N1 - Funding Information: We thank Dr. B.L. Vallee for continued advice and support, Dr. J.L. Bethune for statistical analysis of the CAM results, and Mr. Douglas S. Auld for assistance in preparing synthetic peptides. This work was supported by the Endowment for Research in Human Biology, Inc. and in part by funds from Hoechst, A.G. under agreements with Harvard University.

PY - 1989/7/14

Y1 - 1989/7/14

N2 - Synthetic peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal peptides also inhibit nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.

AB - Synthetic peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal peptides also inhibit nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.

UR - https://www.scopus.com/pages/publications/0024359605

UR - https://www.scopus.com/pages/publications/0024359605#tab=citedBy

U2 - 10.1016/0006-291X(89)92030-5

DO - 10.1016/0006-291X(89)92030-5

M3 - Article

C2 - 2473749

AN - SCOPUS:0024359605

SN - 0006-291X

VL - 162

SP - 535

EP - 543

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto