Ca 2+ regulation and gene expression in normal brain aging

Emil C. Toescu; Alexei Verkhratsky; Philip W. Landfield

doi:10.1016/j.tins.2004.07.010

Ca ²⁺ regulation and gene expression in normal brain aging

Emil C. Toescu
, Alexei Verkhratsky
, Philip W. Landfield

Pharmacology and Nutritional Sciences

Producción científica: Review article › revisión exhaustiva

205 Citas (Scopus)

Resumen

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca ²⁺ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca ²⁺ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

Idioma original	English
Páginas (desde-hasta)	614-620
Número de páginas	7
Publicación	Trends in Neurosciences
Volumen	27
N.º	10
DOI	https://doi.org/10.1016/j.tins.2004.07.010
Estado	Published - oct 2004

Nota bibliográfica

Funding Information:
E.C.T. and A.V. thank the BBSRC, which funded, through the Science of Ageing Initiative, part of the work described in this review. Aspects of the research were also supported by grants AG04542 and AG10836 from the NIA to P.L.

Financiación

E.C.T. and A.V. thank the BBSRC, which funded, through the Science of Ageing Initiative, part of the work described in this review. Aspects of the research were also supported by grants AG04542 and AG10836 from the NIA to P.L.

Financiadores	Número del financiador
National Institute on Aging	P01AG010836
National Institute on Aging
Biotechnology and Biological Sciences Research Council	AG04542
Biotechnology and Biological Sciences Research Council

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.tins.2004.07.010

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