Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance

Valery Adorno-Cruz; Golam Kibria; Xia Liu; Mary Doherty; Damian J. Junk; Dongyin Guan; Chris Hubert; Monica Venere; Erin Mulkearns-Hubert; Maksim Sinyuk; Alvaro Alvarado; Arnold I. Caplan; Jeremy Rich; Stanton L. Gerson; Justin Lathia; Huiping Liu

doi:10.1158/0008-5472.CAN-14-3225

Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance

Valery Adorno-Cruz, Golam Kibria, Xia Liu, Mary Doherty, Damian J. Junk, Dongyin Guan, Chris Hubert, Monica Venere, Erin Mulkearns-Hubert, Maksim Sinyuk, Alvaro Alvarado, Arnold I. Caplan, Jeremy Rich, Stanton L. Gerson, Justin Lathia, Huiping Liu

Toxicology and Cancer Biology

Producción científica: Article › revisión exhaustiva

210 Citas (Scopus)

Resumen

With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.

Idioma original	English
Páginas (desde-hasta)	924-929
Número de páginas	6
Publicación	Cancer Research
Volumen	75
N.º	6
DOI	https://doi.org/10.1158/0008-5472.CAN-14-3225
Estado	Published - mar 15 2015

Nota bibliográfica

Publisher Copyright:
©2015 AACR.

Financiación

Financiadores	Número del financiador
National Childhood Cancer Registry – National Cancer Institute	P30 CA043703
National Childhood Cancer Registry – National Cancer Institute	P30CA043703

ASJC Scopus subject areas

Oncology
Cancer Research

ODS de las Naciones Unidas

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Adorno-Cruz, V., Kibria, G., Liu, X., Doherty, M., Junk, D. J., Guan, D., Hubert, C., Venere, M., Mulkearns-Hubert, E., Sinyuk, M., Alvarado, A., Caplan, A. I., Rich, J., Gerson, S. L., Lathia, J., & Liu, H. (2015). Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Research, 75(6), 924-929. https://doi.org/10.1158/0008-5472.CAN-14-3225

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title = "Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance",

abstract = "With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.",

author = "Valery Adorno-Cruz and Golam Kibria and Xia Liu and Mary Doherty and Junk, \{Damian J.\} and Dongyin Guan and Chris Hubert and Monica Venere and Erin Mulkearns-Hubert and Maksim Sinyuk and Alvaro Alvarado and Caplan, \{Arnold I.\} and Jeremy Rich and Gerson, \{Stanton L.\} and Justin Lathia and Huiping Liu",

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doi = "10.1158/0008-5472.CAN-14-3225",

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Adorno-Cruz, V, Kibria, G, Liu, X, Doherty, M, Junk, DJ, Guan, D, Hubert, C, Venere, M, Mulkearns-Hubert, E, Sinyuk, M, Alvarado, A, Caplan, AI, Rich, J, Gerson, SL, Lathia, J & Liu, H 2015, 'Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance', Cancer Research, vol. 75, n.º 6, pp. 924-929. https://doi.org/10.1158/0008-5472.CAN-14-3225

TY - JOUR

T1 - Cancer stem cells

T2 - Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance

AU - Adorno-Cruz, Valery

AU - Kibria, Golam

AU - Liu, Xia

AU - Doherty, Mary

AU - Junk, Damian J.

AU - Guan, Dongyin

AU - Hubert, Chris

AU - Venere, Monica

AU - Mulkearns-Hubert, Erin

AU - Sinyuk, Maksim

AU - Alvarado, Alvaro

AU - Caplan, Arnold I.

AU - Rich, Jeremy

AU - Gerson, Stanton L.

AU - Lathia, Justin

AU - Liu, Huiping

PY - 2015/3/15

Y1 - 2015/3/15

N2 - With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.

AB - With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer.

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Cancer stem cells: Targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

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