Caveolae, lipid rafts, and vascular disease

Xiang An Li; William V. Everson; Eric J. Smart

doi:10.1016/j.tcm.2005.04.001

Caveolae, lipid rafts, and vascular disease

Xiang An Li, William V. Everson, Eric J. Smart

Physiology

Producción científica: Review article › revisión exhaustiva

88 Citas (Scopus)

Resumen

Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

Idioma original	English
Páginas (desde-hasta)	92-96
Número de páginas	5
Publicación	Trends in Cardiovascular Medicine
Volumen	15
N.º	3
DOI	https://doi.org/10.1016/j.tcm.2005.04.001
Estado	Published - abr 2005

Nota bibliográfica

Funding Information:
The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).

Financiación

The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).

Financiadores	Número del financiador
Corporacion Nacional del Cobre	P20 RR15592
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)	R01HL062844, HL64056
National Center for Research Resources

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Acceder al documento

10.1016/j.tcm.2005.04.001

Otros archivos y enlaces

Citar esto

@article{faadcfd121e04964ab02d1b36c69ea57,

title = "Caveolae, lipid rafts, and vascular disease",

abstract = "Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.",

author = "Li, \{Xiang An\} and Everson, \{William V.\} and Smart, \{Eric J.\}",

note = "Funding Information: The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).",

year = "2005",

month = apr,

doi = "10.1016/j.tcm.2005.04.001",

language = "English",

volume = "15",

pages = "92--96",

number = "3",

}

TY - JOUR

T1 - Caveolae, lipid rafts, and vascular disease

AU - Li, Xiang An

AU - Everson, William V.

AU - Smart, Eric J.

N1 - Funding Information: The authors thank the Cardiovascular Research Center and Pediatric Research Center for invaluable advice and assistance. This work was supported, in part, by a COBRE grant (P20 RR15592) from the National Center for Research Resources at the National Institutes of Health and by the National Heart, Lung, and Blood Institute (HL62844, HL64056: EJS).

PY - 2005/4

Y1 - 2005/4

N2 - Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

AB - Caveolae and lipid rafts are discrete regions within the plasma membrane that coordinate and regulate a variety of signaling processes. The exact relationship between caveolae and lipid rafts is unclear. However, caveolae contain a protein called caveolin that serves as a biochemical marker for caveolae. In addition, caveolin plays a role in maintaining the lipid composition of caveolae, the morphology of caveolae, and the signals that emanate from caveolae. The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy. In this review, we will focus on the role of caveolae in the cardiovascular system.

UR - http://www.scopus.com/inward/record.url?scp=22544443358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22544443358&partnerID=8YFLogxK

U2 - 10.1016/j.tcm.2005.04.001

DO - 10.1016/j.tcm.2005.04.001

M3 - Review article

C2 - 16039968

AN - SCOPUS:22544443358

SN - 1050-1738

VL - 15

SP - 92

EP - 96

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 3

ER -

Caveolae, lipid rafts, and vascular disease

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto