Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study

Priya Palta; A. Richey Sharrett; Jingkai Wei; Michelle L. Meyer; Anna Kucharska-Newton; Melinda C. Power; Jennifer A. Deal; Clifford R. Jack; David Knopman; Jacqueline Wright; Michael Griswold; Hirofumi Tanaka; Thomas H. Mosley; Gerardo Heiss

doi:10.1161/JAHA.118.011045

Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study

Priya Palta
, A. Richey Sharrett
, Jingkai Wei
, Michelle L. Meyer
, Anna Kucharska-Newton
, Melinda C. Power
, Jennifer A. Deal
, Clifford R. Jack
, David Knopman
, Jacqueline Wright
, Michael Griswold
, Hirofumi Tanaka
, Thomas H. Mosley
, Gerardo Heiss

Epidemiology & Environmental Health

Producción científica: Article › revisión exhaustiva

91 Citas (Scopus)

Resumen

Background Central arterial stiffening and increased pulsatility, with consequent cerebral hypoperfusion, may result in structural brain damage and cognitive impairment. Methods and Results We analyzed a cross‐sectional sample of ARIC‐NCS(Atherosclerosis Risk in Communities–Neurocognitive Study) participants (aged 67–90 years, 60% women) with measures of cognition (n=3703) and brain magnetic resonance imaging (n=1255). Central arterial hemodynamics were assessed as carotid‐femoral pulse wave velocity and pressure pulsatility (central pulse pressure). We derived factor scores for cognitive domains. Brain magnetic resonance imaging using 3‐Tesla scanners quantified lacunar infarcts; cerebral microbleeds; and volumes of white matter hyperintensities, total brain, and the Alzheimer disease signature region. We used logistic regression, adjusted for demographics, apolipoprotein E ɛ4, heart rate, mean arterial pressure, and select cardiovascular risk factors, to estimate the odds of lacunar infarcts or cerebral microbleeds. Linear regression, additionally adjusted for intracranial volume, estimated the difference in log‐transformed volumes of white matter hyperintensities, total brain, and the Alzheimer diseasesignature region. We estimated the mean difference in cognitive factor scores across quartiles of carotid‐femoral pulse wave velocity or central pulse pressure using linear regression. Compared with participants in the lowest carotid‐femoral pulse wave velocity quartile, participants in the highest quartile of carotid‐femoral pulse wave velocity had a greater burden of white matter hyperintensities (P=0.007 for trend), smaller total brain volumes (−18.30 cm ³ ; 95% CI, −27.54 to −9.07 cm ³ ), and smaller Alzheimer disease signature region volumes (−1.48 cm ³ ; 95% CI, −2.27 to −0.68 cm ³ ). These participants also had lower scores in executive function/processing speed (β=−0.04 z score; 95% CI, −0.07 to −0.01 z score) and general cognition (β=−0.09 z score; 95% CI, −0.15 to −0.03 z score). Similar results were observed for central pulse pressure. Conclusions Central arterial hemodynamics were associated with structural brain damage and poorer cognitive performance among older adults.

Idioma original	English
Número de artículo	e011045
Publicación	Journal of the American Heart Association
Volumen	8
N.º	2
DOI	https://doi.org/10.1161/JAHA.118.011045
Estado	Published - ene 1 2019

Nota bibliográfica

Publisher Copyright:
© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

Financiación

The ARIC (Atherosclerosis Risk in Communities) Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201700004I). Neurocognitive data is collected by U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD), and with previous brain magnetic resonance imaging examinations funded by R01‐HL70825 from the National Heart, Lung, and Blood Institute. Additional support was provided by the National Institute on Aging for the measures of arterial stiffness and pressure pulsatility (R01AG053938). Dr Palta is supported by grant K99AG052830 from the National Institute on Aging. Dr Deal is supported by grant K01AG054693 from the National Institute on Aging. The views expressed herein are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institute on Aging; the National Institutes of Health; or the US Department of Health and Human Services. The ARIC (Atherosclerosis Risk in Communities) Study is carried out asacollaborativestudysupportedbyNationalHeart,Lung,andBlood Institutecontracts(HHSN268201700001I,HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268 201700004I). Neurocognitive data is collected by U01 2U01HL0 96812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01 HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD), and with previous brain magnetic resonance imaging examinations funded by R01-HL70825 from the National Heart, Lung, and Blood Institute. AdditionalsupportwasprovidedbytheNationalInstituteonAgingfor the measures of arterial stiffness and pressure pulsatility (R01AG053938). Dr Palta is supported by grant K99AG052830 from the National Institute on Aging. Dr Deal is supported by grant K01AG054693 from the National Institute on Aging. The views expressed herein are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institute on Aging; the National Institutes of Health; or the US Department of Health and Human Services.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute on Aging	K99AG052830, K01AG054693
National Heart, Lung, and Blood Institute (NHLBI)	HHSN268201700005I
National Institute on Deafness and Other Communication Disorders	R01-HL70825
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/JAHA.118.011045

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Palta, P., Sharrett, A. R., Wei, J., Meyer, M. L., Kucharska-Newton, A., Power, M. C., Deal, J. A., Jack, C. R., Knopman, D., Wright, J., Griswold, M., Tanaka, H., Mosley, T. H., & Heiss, G. (2019). Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study. Journal of the American Heart Association, 8(2), Artículo e011045. https://doi.org/10.1161/JAHA.118.011045

@article{cc6e42526632499bb657b4c0cd77f880,

title = "Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study",

abstract = " Background Central arterial stiffening and increased pulsatility, with consequent cerebral hypoperfusion, may result in structural brain damage and cognitive impairment. Methods and Results We analyzed a cross‐sectional sample of ARIC‐NCS(Atherosclerosis Risk in Communities–Neurocognitive Study) participants (aged 67–90 years, 60\% women) with measures of cognition (n=3703) and brain magnetic resonance imaging (n=1255). Central arterial hemodynamics were assessed as carotid‐femoral pulse wave velocity and pressure pulsatility (central pulse pressure). We derived factor scores for cognitive domains. Brain magnetic resonance imaging using 3‐Tesla scanners quantified lacunar infarcts; cerebral microbleeds; and volumes of white matter hyperintensities, total brain, and the Alzheimer disease signature region. We used logistic regression, adjusted for demographics, apolipoprotein E ɛ4, heart rate, mean arterial pressure, and select cardiovascular risk factors, to estimate the odds of lacunar infarcts or cerebral microbleeds. Linear regression, additionally adjusted for intracranial volume, estimated the difference in log‐transformed volumes of white matter hyperintensities, total brain, and the Alzheimer diseasesignature region. We estimated the mean difference in cognitive factor scores across quartiles of carotid‐femoral pulse wave velocity or central pulse pressure using linear regression. Compared with participants in the lowest carotid‐femoral pulse wave velocity quartile, participants in the highest quartile of carotid‐femoral pulse wave velocity had a greater burden of white matter hyperintensities (P=0.007 for trend), smaller total brain volumes (−18.30 cm 3 ; 95\% CI, −27.54 to −9.07 cm 3 ), and smaller Alzheimer disease signature region volumes (−1.48 cm 3 ; 95\% CI, −2.27 to −0.68 cm 3 ). These participants also had lower scores in executive function/processing speed (β=−0.04 z score; 95\% CI, −0.07 to −0.01 z score) and general cognition (β=−0.09 z score; 95\% CI, −0.15 to −0.03 z score). Similar results were observed for central pulse pressure. Conclusions Central arterial hemodynamics were associated with structural brain damage and poorer cognitive performance among older adults.",

keywords = "Arterial stiffness, Cognition, Magnetic resonance imaging, Pulse wave velocity",

author = "Priya Palta and Sharrett, \{A. Richey\} and Jingkai Wei and Meyer, \{Michelle L.\} and Anna Kucharska-Newton and Power, \{Melinda C.\} and Deal, \{Jennifer A.\} and Jack, \{Clifford R.\} and David Knopman and Jacqueline Wright and Michael Griswold and Hirofumi Tanaka and Mosley, \{Thomas H.\} and Gerardo Heiss",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.",

year = "2019",

month = jan,

day = "1",

doi = "10.1161/JAHA.118.011045",

language = "English",

volume = "8",

number = "2",

}

Palta, P, Sharrett, AR, Wei, J, Meyer, ML, Kucharska-Newton, A, Power, MC, Deal, JA, Jack, CR, Knopman, D, Wright, J, Griswold, M, Tanaka, H, Mosley, TH & Heiss, G 2019, 'Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study', Journal of the American Heart Association, vol. 8, n.º 2, e011045. https://doi.org/10.1161/JAHA.118.011045

TY - JOUR

T1 - Central arterial stiffness is associated with structural brain damage and poorer cognitive performance

T2 - The ARIC study

AU - Palta, Priya

AU - Sharrett, A. Richey

AU - Wei, Jingkai

AU - Meyer, Michelle L.

AU - Kucharska-Newton, Anna

AU - Power, Melinda C.

AU - Deal, Jennifer A.

AU - Jack, Clifford R.

AU - Knopman, David

AU - Wright, Jacqueline

AU - Griswold, Michael

AU - Tanaka, Hirofumi

AU - Mosley, Thomas H.

AU - Heiss, Gerardo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background Central arterial stiffening and increased pulsatility, with consequent cerebral hypoperfusion, may result in structural brain damage and cognitive impairment. Methods and Results We analyzed a cross‐sectional sample of ARIC‐NCS(Atherosclerosis Risk in Communities–Neurocognitive Study) participants (aged 67–90 years, 60% women) with measures of cognition (n=3703) and brain magnetic resonance imaging (n=1255). Central arterial hemodynamics were assessed as carotid‐femoral pulse wave velocity and pressure pulsatility (central pulse pressure). We derived factor scores for cognitive domains. Brain magnetic resonance imaging using 3‐Tesla scanners quantified lacunar infarcts; cerebral microbleeds; and volumes of white matter hyperintensities, total brain, and the Alzheimer disease signature region. We used logistic regression, adjusted for demographics, apolipoprotein E ɛ4, heart rate, mean arterial pressure, and select cardiovascular risk factors, to estimate the odds of lacunar infarcts or cerebral microbleeds. Linear regression, additionally adjusted for intracranial volume, estimated the difference in log‐transformed volumes of white matter hyperintensities, total brain, and the Alzheimer diseasesignature region. We estimated the mean difference in cognitive factor scores across quartiles of carotid‐femoral pulse wave velocity or central pulse pressure using linear regression. Compared with participants in the lowest carotid‐femoral pulse wave velocity quartile, participants in the highest quartile of carotid‐femoral pulse wave velocity had a greater burden of white matter hyperintensities (P=0.007 for trend), smaller total brain volumes (−18.30 cm 3 ; 95% CI, −27.54 to −9.07 cm 3 ), and smaller Alzheimer disease signature region volumes (−1.48 cm 3 ; 95% CI, −2.27 to −0.68 cm 3 ). These participants also had lower scores in executive function/processing speed (β=−0.04 z score; 95% CI, −0.07 to −0.01 z score) and general cognition (β=−0.09 z score; 95% CI, −0.15 to −0.03 z score). Similar results were observed for central pulse pressure. Conclusions Central arterial hemodynamics were associated with structural brain damage and poorer cognitive performance among older adults.

AB - Background Central arterial stiffening and increased pulsatility, with consequent cerebral hypoperfusion, may result in structural brain damage and cognitive impairment. Methods and Results We analyzed a cross‐sectional sample of ARIC‐NCS(Atherosclerosis Risk in Communities–Neurocognitive Study) participants (aged 67–90 years, 60% women) with measures of cognition (n=3703) and brain magnetic resonance imaging (n=1255). Central arterial hemodynamics were assessed as carotid‐femoral pulse wave velocity and pressure pulsatility (central pulse pressure). We derived factor scores for cognitive domains. Brain magnetic resonance imaging using 3‐Tesla scanners quantified lacunar infarcts; cerebral microbleeds; and volumes of white matter hyperintensities, total brain, and the Alzheimer disease signature region. We used logistic regression, adjusted for demographics, apolipoprotein E ɛ4, heart rate, mean arterial pressure, and select cardiovascular risk factors, to estimate the odds of lacunar infarcts or cerebral microbleeds. Linear regression, additionally adjusted for intracranial volume, estimated the difference in log‐transformed volumes of white matter hyperintensities, total brain, and the Alzheimer diseasesignature region. We estimated the mean difference in cognitive factor scores across quartiles of carotid‐femoral pulse wave velocity or central pulse pressure using linear regression. Compared with participants in the lowest carotid‐femoral pulse wave velocity quartile, participants in the highest quartile of carotid‐femoral pulse wave velocity had a greater burden of white matter hyperintensities (P=0.007 for trend), smaller total brain volumes (−18.30 cm 3 ; 95% CI, −27.54 to −9.07 cm 3 ), and smaller Alzheimer disease signature region volumes (−1.48 cm 3 ; 95% CI, −2.27 to −0.68 cm 3 ). These participants also had lower scores in executive function/processing speed (β=−0.04 z score; 95% CI, −0.07 to −0.01 z score) and general cognition (β=−0.09 z score; 95% CI, −0.15 to −0.03 z score). Similar results were observed for central pulse pressure. Conclusions Central arterial hemodynamics were associated with structural brain damage and poorer cognitive performance among older adults.

KW - Arterial stiffness

KW - Cognition

KW - Magnetic resonance imaging

KW - Pulse wave velocity

UR - https://www.scopus.com/pages/publications/85060058258

UR - https://www.scopus.com/pages/publications/85060058258#tab=citedBy

U2 - 10.1161/JAHA.118.011045

DO - 10.1161/JAHA.118.011045

M3 - Article

C2 - 30646799

AN - SCOPUS:85060058258

SN - 2047-9980

VL - 8

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 2

M1 - e011045

ER -

Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study

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