Challenges for emerging neurostimulation-based therapies for real-time seizure control

Sridhar Sunderam; Sachin S. Talathi; Alexey Lyubushin; Didier Sornette; Ivan Osorio

doi:10.1016/j.yebeh.2011.04.007

Challenges for emerging neurostimulation-based therapies for real-time seizure control

Sridhar Sunderam, Sachin S. Talathi, Alexey Lyubushin, Didier Sornette, Ivan Osorio

Biomedical Engineering

Producción científica: Review article › revisión exhaustiva

7 Citas (Scopus)

Resumen

In step with the worthwhile aim of this special issue, two junior investigators impart their insights on the therapeutic challenges imposed by pharmacoresistant epilepsies and offer viable approaches to improvement of treatment outcomes. Sunderam's comprehensive perspective addresses issues of critical importance for the design of efficacious therapies. Talathi delves into the thorny roles of so-called "interictal" spikes in ictio- and epileptogenesis, roles that are central to understanding the dynamics of these phenomena and implicitly of how to prevent them or abort them. First, however, Osorio and co-workers illustrate the complex behavior of the epileptogenic network and point to the importance of real-time intraindividual adaptation and optimization of therapies for seizures originating from the same epileptogenic network.

Idioma original	English
Páginas (desde-hasta)	118-125
Número de páginas	8
Publicación	Epilepsy and Behavior
Volumen	22
N.º	1
DOI	https://doi.org/10.1016/j.yebeh.2011.04.007
Estado	Published - sept 2011

Nota bibliográfica

Funding Information:
Sridhar Sunderam is grateful for support from NINDS and the Epilepsy Foundation, and for the opportunity to learn from some outstanding epilepsy researchers: Ivan Osorio, Mark Frei, Bruce Gluckman, Steven Schiff, and Steven Weinstein. Most of the author's work cited here was performed in collaboration with them.

Funding Information:
Sachin S. Talathi acknowledges past support from the Epilepsy Foundation of America, active support through an intramural grant from the University of Florida, the Wilder Center of Excellence for Epilepsy Research, and the Children's Miracle Network, and an opportunity to learn and collaborate with outstanding clinical and basic scientists: Paul Carney, William Ditto, Dong-Uk Hwang, and Pramod Khargonekar.

Financiación

Sridhar Sunderam is grateful for support from NINDS and the Epilepsy Foundation, and for the opportunity to learn from some outstanding epilepsy researchers: Ivan Osorio, Mark Frei, Bruce Gluckman, Steven Schiff, and Steven Weinstein. Most of the author's work cited here was performed in collaboration with them. Sachin S. Talathi acknowledges past support from the Epilepsy Foundation of America, active support through an intramural grant from the University of Florida, the Wilder Center of Excellence for Epilepsy Research, and the Children's Miracle Network, and an opportunity to learn and collaborate with outstanding clinical and basic scientists: Paul Carney, William Ditto, Dong-Uk Hwang, and Pramod Khargonekar.

Financiadores	Número del financiador
Children's Miracle Network Fund for Sithisarn
Wilder Center of Excellence for Epilepsy Research
National Institute of Neurological Disorders and Stroke
Epilepsy Foundation of America
Florida A and M University

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

Acceder al documento

10.1016/j.yebeh.2011.04.007

Otros archivos y enlaces

Citar esto

@article{3b481ec4e08041b3b888ec8f5cd114ca,

title = "Challenges for emerging neurostimulation-based therapies for real-time seizure control",

abstract = "In step with the worthwhile aim of this special issue, two junior investigators impart their insights on the therapeutic challenges imposed by pharmacoresistant epilepsies and offer viable approaches to improvement of treatment outcomes. Sunderam's comprehensive perspective addresses issues of critical importance for the design of efficacious therapies. Talathi delves into the thorny roles of so-called {"}interictal{"} spikes in ictio- and epileptogenesis, roles that are central to understanding the dynamics of these phenomena and implicitly of how to prevent them or abort them. First, however, Osorio and co-workers illustrate the complex behavior of the epileptogenic network and point to the importance of real-time intraindividual adaptation and optimization of therapies for seizures originating from the same epileptogenic network.",

keywords = "Anisotropy, Clusters, Current flow, Electrotherapy, Neuropil-electrode interface, Nonstationarity, Optimization, Real time, Seizures, Spectral properties",

author = "Sridhar Sunderam and Talathi, \{Sachin S.\} and Alexey Lyubushin and Didier Sornette and Ivan Osorio",

note = "Funding Information: Sridhar Sunderam is grateful for support from NINDS and the Epilepsy Foundation, and for the opportunity to learn from some outstanding epilepsy researchers: Ivan Osorio, Mark Frei, Bruce Gluckman, Steven Schiff, and Steven Weinstein. Most of the author's work cited here was performed in collaboration with them. Funding Information: Sachin S. Talathi acknowledges past support from the Epilepsy Foundation of America, active support through an intramural grant from the University of Florida, the Wilder Center of Excellence for Epilepsy Research, and the Children's Miracle Network, and an opportunity to learn and collaborate with outstanding clinical and basic scientists: Paul Carney, William Ditto, Dong-Uk Hwang, and Pramod Khargonekar. ",

year = "2011",

month = sep,

doi = "10.1016/j.yebeh.2011.04.007",

language = "English",

volume = "22",

pages = "118--125",

number = "1",

}

TY - JOUR

T1 - Challenges for emerging neurostimulation-based therapies for real-time seizure control

AU - Sunderam, Sridhar

AU - Talathi, Sachin S.

AU - Lyubushin, Alexey

AU - Sornette, Didier

AU - Osorio, Ivan

N1 - Funding Information: Sridhar Sunderam is grateful for support from NINDS and the Epilepsy Foundation, and for the opportunity to learn from some outstanding epilepsy researchers: Ivan Osorio, Mark Frei, Bruce Gluckman, Steven Schiff, and Steven Weinstein. Most of the author's work cited here was performed in collaboration with them. Funding Information: Sachin S. Talathi acknowledges past support from the Epilepsy Foundation of America, active support through an intramural grant from the University of Florida, the Wilder Center of Excellence for Epilepsy Research, and the Children's Miracle Network, and an opportunity to learn and collaborate with outstanding clinical and basic scientists: Paul Carney, William Ditto, Dong-Uk Hwang, and Pramod Khargonekar.

PY - 2011/9

Y1 - 2011/9

N2 - In step with the worthwhile aim of this special issue, two junior investigators impart their insights on the therapeutic challenges imposed by pharmacoresistant epilepsies and offer viable approaches to improvement of treatment outcomes. Sunderam's comprehensive perspective addresses issues of critical importance for the design of efficacious therapies. Talathi delves into the thorny roles of so-called "interictal" spikes in ictio- and epileptogenesis, roles that are central to understanding the dynamics of these phenomena and implicitly of how to prevent them or abort them. First, however, Osorio and co-workers illustrate the complex behavior of the epileptogenic network and point to the importance of real-time intraindividual adaptation and optimization of therapies for seizures originating from the same epileptogenic network.

AB - In step with the worthwhile aim of this special issue, two junior investigators impart their insights on the therapeutic challenges imposed by pharmacoresistant epilepsies and offer viable approaches to improvement of treatment outcomes. Sunderam's comprehensive perspective addresses issues of critical importance for the design of efficacious therapies. Talathi delves into the thorny roles of so-called "interictal" spikes in ictio- and epileptogenesis, roles that are central to understanding the dynamics of these phenomena and implicitly of how to prevent them or abort them. First, however, Osorio and co-workers illustrate the complex behavior of the epileptogenic network and point to the importance of real-time intraindividual adaptation and optimization of therapies for seizures originating from the same epileptogenic network.

KW - Anisotropy

KW - Clusters

KW - Current flow

KW - Electrotherapy

KW - Neuropil-electrode interface

KW - Nonstationarity

KW - Optimization

KW - Real time

KW - Seizures

KW - Spectral properties

UR - https://www.scopus.com/pages/publications/80052446500

UR - https://www.scopus.com/inward/citedby.url?scp=80052446500&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2011.04.007

DO - 10.1016/j.yebeh.2011.04.007

M3 - Review article

C2 - 21664192

AN - SCOPUS:80052446500

SN - 1525-5050

VL - 22

SP - 118

EP - 125

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 1

ER -

Challenges for emerging neurostimulation-based therapies for real-time seizure control

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto