Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Rick A. Bevins; Timothy A. Delzer; Michael T. Bardo

doi:10.1016/0091-3057(95)02071-3

Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Rick A. Bevins
, Timothy A. Delzer
, Michael T. Bardo

Producción científica: Article › revisión exhaustiva

7 Citas (Scopus)

Resumen

Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D₃ agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

Idioma original	English
Páginas (desde-hasta)	695-699
Número de páginas	5
Publicación	Pharmacology Biochemistry and Behavior
Volumen	53
N.º	3
DOI	https://doi.org/10.1016/0091-3057(95)02071-3
Estado	Published - mar 1996

Nota bibliográfica

Funding Information:
This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.

Financiación

This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.

Financiadores	Número del financiador
National Institute on Drug Abuse	R01DA007746
U.S. Public Health Service	DA05312, DA05623, DA07746

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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@article{67a2e850207b44909333166062f62f13,

title = "Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats",

abstract = "Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1\% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.",

keywords = "7-Hydroxy-N,N-di-n-propyl-2-aminotetralin, 7-OH-DPAT, Amphetamine, Cocaine, D receptor, D receptor, Dopamine, Reward, Saccharin taste aversion, Sigma receptor",

author = "Bevins, \{Rick A.\} and Delzer, \{Timothy A.\} and Bardo, \{Michael T.\}",

note = "Funding Information: This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.",

year = "1996",

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doi = "10.1016/0091-3057(95)02071-3",

language = "English",

volume = "53",

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T1 - Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

AU - Bevins, Rick A.

AU - Delzer, Timothy A.

AU - Bardo, Michael T.

N1 - Funding Information: This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.

PY - 1996/3

Y1 - 1996/3

N2 - Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

AB - Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

KW - 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin

KW - 7-OH-DPAT

KW - Amphetamine

KW - Cocaine

KW - D receptor

KW - Dopamine

KW - Reward

KW - Saccharin taste aversion

KW - Sigma receptor

UR - https://www.scopus.com/pages/publications/0029929643

UR - https://www.scopus.com/pages/publications/0029929643#tab=citedBy

U2 - 10.1016/0091-3057(95)02071-3

DO - 10.1016/0091-3057(95)02071-3

M3 - Article

C2 - 8866974

AN - SCOPUS:0029929643

SN - 0091-3057

VL - 53

SP - 695

EP - 699

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 3

ER -

Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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