Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents

Birgit Schilling; Christopher J. Collins; Malin M. Young; Xin Guo; Irwin D. Kuntz; Andrew D. Leavitt; Kip Guy; Bradford W. Gibson

Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents

Birgit Schilling
, Christopher J. Collins
, Malin M. Young
, Xin Guo
, Irwin D. Kuntz
, Andrew D. Leavitt
, Kip Guy
, Bradford W. Gibson

Producción científica: Paper › revisión exhaustiva

1 Cita (Scopus)

Resumen

Chemical cross-linking strategies to determine protein conformation were discussed. Several model proteins such as myoglobin and cytochrome C were reacted with a combinatorial set of amine-specific cross-linking reagents. The set of crosslinkers with different spacers provided different maximum distance constraints between targeted residues. High performance liquid chromatography and mass spectrometry were used to confirm peptide cross-links and to investigate fragmentation pathways.

Idioma original	English
Páginas	125-126
Número de páginas	2
Estado	Published - 2002
Evento	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duración: jun 2 2002 → jun 6 2002

Conference

Conference	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
País/Territorio	United States
Ciudad	Orlando, FL
Período	6/2/02 → 6/6/02

ASJC Scopus subject areas

Spectroscopy

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@conference{3ede72074d174db2a3e75f8c9608417d,

title = "Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents",

abstract = "Chemical cross-linking strategies to determine protein conformation were discussed. Several model proteins such as myoglobin and cytochrome C were reacted with a combinatorial set of amine-specific cross-linking reagents. The set of crosslinkers with different spacers provided different maximum distance constraints between targeted residues. High performance liquid chromatography and mass spectrometry were used to confirm peptide cross-links and to investigate fragmentation pathways.",

author = "Birgit Schilling and Collins, \{Christopher J.\} and Young, \{Malin M.\} and Xin Guo and Kuntz, \{Irwin D.\} and Leavitt, \{Andrew D.\} and Kip Guy and Gibson, \{Bradford W.\}",

year = "2002",

language = "English",

pages = "125--126",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

}

Schilling, B, Collins, CJ, Young, MM, Guo, X, Kuntz, ID, Leavitt, AD, Guy, K & Gibson, BW 2002, 'Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents', Papel presentado en Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02 - 6/6/02 pp. 125-126.

Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents. / Schilling, Birgit; Collins, Christopher J.; Young, Malin M. et al.
2002. 125-126 Papel presentado en Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Producción científica: Paper › revisión exhaustiva

TY - CONF

T1 - Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents

AU - Schilling, Birgit

AU - Collins, Christopher J.

AU - Young, Malin M.

AU - Guo, Xin

AU - Kuntz, Irwin D.

AU - Leavitt, Andrew D.

AU - Guy, Kip

AU - Gibson, Bradford W.

PY - 2002

Y1 - 2002

N2 - Chemical cross-linking strategies to determine protein conformation were discussed. Several model proteins such as myoglobin and cytochrome C were reacted with a combinatorial set of amine-specific cross-linking reagents. The set of crosslinkers with different spacers provided different maximum distance constraints between targeted residues. High performance liquid chromatography and mass spectrometry were used to confirm peptide cross-links and to investigate fragmentation pathways.

AB - Chemical cross-linking strategies to determine protein conformation were discussed. Several model proteins such as myoglobin and cytochrome C were reacted with a combinatorial set of amine-specific cross-linking reagents. The set of crosslinkers with different spacers provided different maximum distance constraints between targeted residues. High performance liquid chromatography and mass spectrometry were used to confirm peptide cross-links and to investigate fragmentation pathways.

UR - https://www.scopus.com/pages/publications/0042246094

UR - https://www.scopus.com/pages/publications/0042246094#tab=citedBy

M3 - Paper

AN - SCOPUS:0042246094

SP - 125

EP - 126

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Chemical cross-linking strategies to determine protein conformation using a combinatorial set of cross-linking reagents

Resumen

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ASJC Scopus subject areas

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