Chemical methods for the synthesis and modification of neoclerodane diterpenes

Anthony Lozama; Thomas E. Prisinzano

doi:10.1016/j.bmcl.2009.07.069

Chemical methods for the synthesis and modification of neoclerodane diterpenes

Anthony Lozama
, Thomas E. Prisinzano

Producción científica: Article › revisión exhaustiva

17 Citas (Scopus)

Resumen

Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

Idioma original	English
Páginas (desde-hasta)	5490-5495
Número de páginas	6
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	19
N.º	18
DOI	https://doi.org/10.1016/j.bmcl.2009.07.069
Estado	Published - sept 15 2009

Nota bibliográfica

Funding Information:
The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.

Financiación

The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.

Financiadores	Número del financiador
National Institutes of Health/National Institute of Environmental Health Sciences
Universities of Iowa and Kansas
National Institute on Drug Abuse	R01DA018151
National Institute of Development Administration	DA018151S1

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.07.069

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title = "Chemical methods for the synthesis and modification of neoclerodane diterpenes",

abstract = "Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.",

keywords = "Diterpene, Neoclerodane, Salvia divinorum, Salvinorin A",

author = "Anthony Lozama and Prisinzano, \{Thomas E.\}",

note = "Funding Information: The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1. ",

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AU - Prisinzano, Thomas E.

N1 - Funding Information: The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.

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N2 - Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

AB - Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

KW - Diterpene

KW - Neoclerodane

KW - Salvia divinorum

KW - Salvinorin A

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VL - 19

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Chemical methods for the synthesis and modification of neoclerodane diterpenes

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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