Chemotherapeutic efficacy of Solanum trilobatum along with paclitaxel in lung cancer bearing swiss albino mice

The present study was conducted to ascertain the chemotherapeutic efficacy of Solanum trilobatum when administered along with paclitaxel against experimental lung carcinogenesis. Healthy male Swiss albino mice (6-8 weeks old) were treated with Benzo (a) pyrene (50 mg kg^-1 body weight) to induce lung cancer. Paclitaxel at a dose of 33 mg kg^-1 body weight intraperitoneally and Solanum irilohatum 200 mg kg^-1 body weight orally was administrated for four weeks to lung cancer bearing animals. The level of lipid peroxides (LPO) was fomd to be markedly increased in carcinogen-administered animals, in contrast the activities/levels of the antioxidant status both in lung and liver were decreased in carcinogen administered animals. Upon Solanum trilobatum along with Paclitaxel administration the above pathological changes were bring back to near normal. From these findings we have concluded that Solanum trilobatum when administered along with paclitaxel prevents LPO and protects antioxidant system strongly aganist Benzo(a)pyrene induced lung cancer.