Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

A. Lysakowski; B. H. Wainer; D. B. Rye; G. Bruce; L. B. Hersh

doi:10.1016/0304-3940(86)90671-3

Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

A. Lysakowski
, B. H. Wainer
, D. B. Rye
, G. Bruce
, L. B. Hersh

Producción científica: Article › revisión exhaustiva

58 Citas (Scopus)

Resumen

A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

Idioma original	English
Páginas (desde-hasta)	102-108
Número de páginas	7
Publicación	Neuroscience Letters
Volumen	64
N.º	1
DOI	https://doi.org/10.1016/0304-3940(86)90671-3
Estado	Published - feb 14 1986

Nota bibliográfica

Funding Information:
We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).

Financiación

We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).

Financiadores	Número del financiador
Brain ResearchF oundation	NS-15739a, AG-05893, PHS 5T32 GM-07281
PHS 5T32 NS-07195	PHS NS-17661, PHS HD-04583, 5T32 NS-07195
McKnight Foundation
Eunice Kennedy Shriver National Institute of Child Health and Human Development	P30HD004583

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(86)90671-3

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@article{8d8dcf576b1a49d3891ff3e21164e367,

title = "Cholinergic innervation displays strikingly different laminar preferences in several cortical areas",

abstract = "A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.",

keywords = "acetylcholine, acetylcholinesterase, choline acetyltransferase, cholinergic system, cortical organization, rat",

author = "A. Lysakowski and Wainer, \{B. H.\} and Rye, \{D. B.\} and G. Bruce and Hersh, \{L. B.\}",

note = "Funding Information: We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).",

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doi = "10.1016/0304-3940(86)90671-3",

language = "English",

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T1 - Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

AU - Lysakowski, A.

AU - Wainer, B. H.

AU - Rye, D. B.

AU - Bruce, G.

AU - Hersh, L. B.

N1 - Funding Information: We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).

PY - 1986/2/14

Y1 - 1986/2/14

N2 - A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

AB - A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

KW - acetylcholine

KW - acetylcholinesterase

KW - choline acetyltransferase

KW - cholinergic system

KW - cortical organization

KW - rat

UR - https://www.scopus.com/pages/publications/0022643524

UR - https://www.scopus.com/pages/publications/0022643524#tab=citedBy

U2 - 10.1016/0304-3940(86)90671-3

DO - 10.1016/0304-3940(86)90671-3

M3 - Article

C2 - 3008035

AN - SCOPUS:0022643524

SN - 0304-3940

VL - 64

SP - 102

EP - 108

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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