TY - JOUR
T1 - Circadian variations in blood pressure, heart rate, and HR-BP cross-correlation coefficient during progression of diabetes mellitus in rat
AU - Anigbogu, Chikodi N.
AU - Williams, Daniel T.
AU - Brown, David R.
AU - Silcox, Dennis L.
AU - Speakman, Richard O.
AU - Brown, Laura C.
AU - Karounos, Dennis G.
AU - Randall, David C.
PY - 2011
Y1 - 2011
N2 - Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n=8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03; P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.
AB - Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n=8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03; P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.
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U2 - 10.4061/2011/738689
DO - 10.4061/2011/738689
M3 - Article
C2 - 21629872
AN - SCOPUS:84865738358
SN - 2090-0384
VL - 2011
JO - International Journal of Hypertension
JF - International Journal of Hypertension
M1 - 738689
ER -
