Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity

Sheng Tong; Sijian Hou; Zhilan Zheng; Jun Zhou; Gang Bao

doi:10.1021/nl102623x

Coating optimization of superparamagnetic iron oxide nanoparticles for high T₂ relaxivity

Sheng Tong
, Sijian Hou
, Zhilan Zheng
, Jun Zhou
, Gang Bao

Producción científica: Article › revisión exhaustiva

421 Citas (Scopus)

Resumen

We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T₂ relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T₂ relaxivity of 385 s^-1 mM^-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

Idioma original	English
Páginas (desde-hasta)	4607-4613
Número de páginas	7
Publicación	Nano Letters
Volumen	10
N.º	11
DOI	https://doi.org/10.1021/nl102623x
Estado	Published - nov 10 2010

Financiación

Financiadores	Número del financiador
National Childhood Cancer Registry – National Cancer Institute	U54CA119338
National Childhood Cancer Registry – National Cancer Institute

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl102623x

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abstract = "We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.",

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AU - Tong, Sheng

AU - Hou, Sijian

AU - Zheng, Zhilan

AU - Zhou, Jun

AU - Bao, Gang

PY - 2010/11/10

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AB - We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

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KW - SPIO

KW - molecular imaging

KW - nuclear relaxation

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