TY - JOUR
T1 - Comment on "Differential rescue of light- and food-entrainable circadian rhythms"
AU - Mistlberger, Ralph E.
AU - Yamazaki, Shin
AU - Pendergast, Julie S.
AU - Landry, Glenn J.
AU - Takumi, Toru
AU - Nakamura, Wataru
PY - 2008/10/31
Y1 - 2008/10/31
N2 - Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.
AB - Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.
UR - https://www.scopus.com/pages/publications/55349123626
UR - https://www.scopus.com/pages/publications/55349123626#tab=citedBy
U2 - 10.1126/science.1161284
DO - 10.1126/science.1161284
M3 - Comment/debate
C2 - 18974333
AN - SCOPUS:55349123626
SN - 0036-8075
VL - 322
SP - 675a
JO - Science
JF - Science
IS - 5902
ER -