Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study

Hiroko H. Dodge; Yuriko Katsumata; Hidemi Todoriki; Shoutoku Yasura; D. Craig Willcox; Gene L. Bowman; Bradley Willcox; Scott Leonard; Aaron Clemons; Barry S. Oken; Jeffrey A. Kaye; Maret G. Traber

doi:10.1093/gerona/glq124

Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study

Hiroko H. Dodge
, Yuriko Katsumata
, Hidemi Todoriki
, Shoutoku Yasura
, D. Craig Willcox
, Gene L. Bowman
, Bradley Willcox
, Scott Leonard
, Aaron Clemons
, Barry S. Oken
, Jeffrey A. Kaye
, Maret G. Traber

Biostatistics

Producción científica: Article › revisión exhaustiva

12 Citas (Scopus)

Resumen

Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

Idioma original	English
Páginas (desde-hasta)	1060-1067
Número de páginas	8
Publicación	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volumen	65 A
N.º	10
DOI	https://doi.org/10.1093/gerona/glq124
Estado	Published - oct 2010

Nota bibliográfica

Funding Information:
This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).

Financiación

This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).

Financiadores	Número del financiador
Oregon Tax Check-off Program for Alzheimer's Research
National Institute on Aging	K01AG023014, P30AG008017
National Center for Complementary and Alternative Medicine	P50 AT00066
Oregon Clinical and Translational Research Institute	UL1 RR024140
Oregon State University
Healthy Aging Research Center

ASJC Scopus subject areas

General Medicine

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10.1093/gerona/glq124

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Dodge, H. H., Katsumata, Y., Todoriki, H., Yasura, S., Willcox, D. C., Bowman, G. L., Willcox, B., Leonard, S., Clemons, A., Oken, B. S., Kaye, J. A., & Traber, M. G. (2010). Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 65 A(10), 1060-1067. https://doi.org/10.1093/gerona/glq124

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title = "Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study",

abstract = "Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.",

keywords = "Circulating micronutrients, Healthy cognitive aging, Okinawa, Oldest old, Oregon",

author = "Dodge, \{Hiroko H.\} and Yuriko Katsumata and Hidemi Todoriki and Shoutoku Yasura and Willcox, \{D. Craig\} and Bowman, \{Gene L.\} and Bradley Willcox and Scott Leonard and Aaron Clemons and Oken, \{Barry S.\} and Kaye, \{Jeffrey A.\} and Traber, \{Maret G.\}",

note = "Funding Information: This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).",

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Dodge, HH, Katsumata, Y, Todoriki, H, Yasura, S, Willcox, DC, Bowman, GL, Willcox, B, Leonard, S, Clemons, A, Oken, BS, Kaye, JA & Traber, MG 2010, 'Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, n.º 10, pp. 1060-1067. https://doi.org/10.1093/gerona/glq124

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T1 - Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders

T2 - A pilot study

AU - Dodge, Hiroko H.

AU - Katsumata, Yuriko

AU - Todoriki, Hidemi

AU - Yasura, Shoutoku

AU - Willcox, D. Craig

AU - Bowman, Gene L.

AU - Willcox, Bradley

AU - Leonard, Scott

AU - Clemons, Aaron

AU - Oken, Barry S.

AU - Kaye, Jeffrey A.

AU - Traber, Maret G.

N1 - Funding Information: This study was supported by the National Institute on Aging ( K01AG023014 to H.H.D.), ( P30 AG08017 to J.A.K.), the National Center for Complementary and Alternative Medicine ( P50 AT00066 to J.A.K.), Linus Pauling Institute Research Grant (H.H.D.), Oregon Tax Check-off Grant (H.H.D.), the Center for Healthy Aging Research Pilot Grant at Oregon State University (H.H.D.), and Oregon Clinical and Translational Research Institution ( UL1 RR024140 ).

PY - 2010/10

Y1 - 2010/10

N2 - Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

AB - Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B12 and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.

KW - Circulating micronutrients

KW - Healthy cognitive aging

KW - Okinawa

KW - Oldest old

KW - Oregon

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DO - 10.1093/gerona/glq124

M3 - Article

C2 - 20643702

AN - SCOPUS:77956893964

SN - 1079-5006

VL - 65 A

SP - 1060

EP - 1067

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 10

ER -

Comparisons of plasma/serum micronutrients between Okinawan and oregonian elders: A pilot study

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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