Computational determination of binding structures and free energies of phosphodiesterase-2 with benzo[1,4]diazepin-2-one derivatives

Chemistry

• Free Energy 100%
• Diazepam 100%
• Enzyme Inhibitor 40%
• Intermolecular Force 40%
• Hydrogen Bonding 20%
• Molecular Dynamics 20%
• Cyclic Adenosine Monophosphate 20%
• Anxiolytic Agent 20%
• Cyclic Guanosine Monophosphate 20%
• Drug Target 20%
• Binding Energy 20%
• Enzymatic Hydrolysis 20%
• Molecular Dynamics Simulation 20%
• Molecular Docking 20%
• Hydrophobic Interaction 20%

Biochemistry, Genetics and Molecular Biology

• Phosphodiesterase 2 100%
• Diazepam 100%
• Enzyme Inhibitor 28%
• Docking (Molecular) 28%
• Dynamics 14%
• Enzymatic Hydrolysis 14%
• Enzyme 14%
• Second Messenger System 14%
• Enhancer Region 14%
• Binding Energy 14%
• Cyclic Adenosine Monophosphate 14%
• Cyclic Guanosine Monophosphate 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Diazepam 100%
• Phosphodiesterase 100%
• Intermolecular Interaction 28%
• Enzyme Inhibitor 28%
• Antidepressant 14%
• Anxiolytic 14%
• Cyclic GMP 14%
• Cyclic AMP 14%