Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Xiaofeng Chen; Hong Lu; Debra L. Rateri; Lisa A. Cassis; Alan Daugherty

doi:10.1016/j.coph.2013.01.002

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Xiaofeng Chen
, Hong Lu
, Debra L. Rateri
, Lisa A. Cassis
, Alan Daugherty

Producción científica: Review article › revisión exhaustiva

48 Citas (Scopus)

Resumen

Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

Idioma original	English
Páginas (desde-hasta)	180-185
Número de páginas	6
Publicación	Current Opinion in Pharmacology
Volumen	13
N.º	2
DOI	https://doi.org/10.1016/j.coph.2013.01.002
Estado	Published - abr 2013

Nota bibliográfica

Funding Information:
The authors’ research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .

Financiación

The authors’ research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .

Financiadores	Número del financiador
National Institutes of Health (NIH)	HL107319
National Heart, Lung, and Blood Institute (NHLBI)	R01HL062846
National Marfan Foundation

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Acceder al documento

10.1016/j.coph.2013.01.002

Otros archivos y enlaces

Citar esto

@article{d34d876407d74c5289b83c0533cf22b0,

title = "Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms",

abstract = "Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.",

author = "Xiaofeng Chen and Hong Lu and Rateri, \{Debra L.\} and Cassis, \{Lisa A.\} and Alan Daugherty",

note = "Funding Information: The authors{\textquoteright} research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .",

year = "2013",

month = apr,

doi = "10.1016/j.coph.2013.01.002",

language = "English",

volume = "13",

pages = "180--185",

number = "2",

}

TY - JOUR

T1 - Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

AU - Chen, Xiaofeng

AU - Lu, Hong

AU - Rateri, Debra L.

AU - Cassis, Lisa A.

AU - Daugherty, Alan

N1 - Funding Information: The authors’ research work was supported by funding from the National Institutes of Health ( HL062846 and HL107319 ). Xiaofeng Chen's research was also supported by a McKusick Fellowship grant from the National Marfan Foundation (NMF) .

PY - 2013/4

Y1 - 2013/4

N2 - Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

AB - Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-β in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-β activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-β in the development of aortic aneurysms.

UR - https://www.scopus.com/pages/publications/84879414073

UR - https://www.scopus.com/pages/publications/84879414073#tab=citedBy

U2 - 10.1016/j.coph.2013.01.002

DO - 10.1016/j.coph.2013.01.002

M3 - Review article

C2 - 23395156

AN - SCOPUS:84879414073

SN - 1471-4892

VL - 13

SP - 180

EP - 185

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

IS - 2

ER -

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto