TY - JOUR
T1 - Crossreaction of monoclonal Anti-T-cell antibodies
T2 - Implications for classifying B-cell leukemias
AU - Munker, R.
AU - Thiel, E.
AU - Kummer, U.
AU - Rodt, H.
AU - Thierfelder, S.
PY - 1983/2
Y1 - 1983/2
N2 - Cell samples from 62 patients with B-cell leukemias (33 CLL, 8 IC, 6 PLL, 4 HCL, 2 ALL and 9 other NHL) were tested with a series of monoclonal antibodies (A50, T101, Lyt2, Leu1, M203) directed against T cells and shown to crossreact with B-CLL. The results demonstrate a heterogeneity of B-cell leukemias as all typical cases of CLL were reactive whereas most other cases were negative. Using the fluorescence-activated cell sorter, a somewhat stronger reaction was seen in early or benign cases of CLL, compared to advanced cases. All B-cell leukemias tested expressed the Ia antigen.
AB - Cell samples from 62 patients with B-cell leukemias (33 CLL, 8 IC, 6 PLL, 4 HCL, 2 ALL and 9 other NHL) were tested with a series of monoclonal antibodies (A50, T101, Lyt2, Leu1, M203) directed against T cells and shown to crossreact with B-CLL. The results demonstrate a heterogeneity of B-cell leukemias as all typical cases of CLL were reactive whereas most other cases were negative. Using the fluorescence-activated cell sorter, a somewhat stronger reaction was seen in early or benign cases of CLL, compared to advanced cases. All B-cell leukemias tested expressed the Ia antigen.
KW - B-cell leukemias
KW - Leukemia markers
KW - Monoclonal antibodies
UR - https://www.scopus.com/pages/publications/0020682171
UR - https://www.scopus.com/inward/citedby.url?scp=0020682171&partnerID=8YFLogxK
U2 - 10.1007/BF00320665
DO - 10.1007/BF00320665
M3 - Article
C2 - 6600407
AN - SCOPUS:0020682171
SN - 0939-5555
VL - 46
SP - 95
EP - 100
JO - Annals of Hematology
JF - Annals of Hematology
IS - 2
ER -