CRP and neutrophils: Functional effects and complex uptake

E. G. Shephard; R. Anderson; A. F. Strachan; S. H. Kühn; F. C. De Beer

CRP and neutrophils: Functional effects and complex uptake

E. G. Shephard
, R. Anderson
, A. F. Strachan
, S. H. Kühn
, F. C. De Beer

Producción científica: Article › revisión exhaustiva

15 Citas (Scopus)

Resumen

The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

Idioma original	English
Páginas (desde-hasta)	718-727
Número de páginas	10
Publicación	Clinical and Experimental Immunology
Volumen	63
N.º	3
Estado	Published - 1986

Nota bibliográfica

Funding Information:
Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).

Financiación

Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "CRP and neutrophils: Functional effects and complex uptake",

abstract = "The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.",

author = "Shephard, \{E. G.\} and R. Anderson and Strachan, \{A. F.\} and K{\"u}hn, \{S. H.\} and \{De Beer\}, \{F. C.\}",

note = "Funding Information: Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane\textasciitilde{}ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).",

year = "1986",

language = "English",

volume = "63",

pages = "718--727",

number = "3",

}

TY - JOUR

T1 - CRP and neutrophils

T2 - Functional effects and complex uptake

AU - Shephard, E. G.

AU - Anderson, R.

AU - Strachan, A. F.

AU - Kühn, S. H.

AU - De Beer, F. C.

N1 - Funding Information: Supported in part by grants from the National Institute of Arthritis and Metabolic Diseases and the National Science Foundation. 2H . Bran£ and F. Chytil, Folia Microbiol (Prague) 11, 43 (1965). D, Monard, J. Jane~ek, and H. ¥. Rickenberg, Biochem. Biophys. Res. Commun. 35, 584 (1969).

PY - 1986

Y1 - 1986

N2 - The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

AB - The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

UR - https://www.scopus.com/pages/publications/0022616165

UR - https://www.scopus.com/pages/publications/0022616165#tab=citedBy

M3 - Article

C2 - 3708910

AN - SCOPUS:0022616165

SN - 0009-9104

VL - 63

SP - 718

EP - 727

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 3

ER -

CRP and neutrophils: Functional effects and complex uptake

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Otros archivos y enlaces

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