TY - JOUR
T1 - Cyclo-oxygenase-1-selective inhibitor SC-560
AU - Long, Sihui
AU - Theiss, Kathryn L.
AU - Li, Tonglei
AU - Loftin, Charles D.
PY - 2009
Y1 - 2009
N2 - In the title compound, 5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-3- (trifluoro-meth-yl)-1H-pyrazole (SC-560), C17H12ClF3N2O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66 (6) and 43.08 (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94 (6)°. No classic hydrogen bonds are possible in the crystal, and intermolecular interactions must be mainly of the dispersion type. This information may aid the identification of dosage formulations with improved oral bioavailability.
AB - In the title compound, 5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-3- (trifluoro-meth-yl)-1H-pyrazole (SC-560), C17H12ClF3N2O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66 (6) and 43.08 (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94 (6)°. No classic hydrogen bonds are possible in the crystal, and intermolecular interactions must be mainly of the dispersion type. This information may aid the identification of dosage formulations with improved oral bioavailability.
UR - https://www.scopus.com/pages/publications/60349120730
UR - https://www.scopus.com/pages/publications/60349120730#tab=citedBy
U2 - 10.1107/S1600536809001779
DO - 10.1107/S1600536809001779
M3 - Article
C2 - 21581958
AN - SCOPUS:60349120730
SN - 1600-5368
VL - 65
SP - o360
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 2
ER -