Cytomegalovirus-related hospitalization is associated with adverse outcomes and increased health-care resource utilization in inflammatory bowel disease

OBJECTIVES: Impact of cytomegalovirus (CMV)-related hospitalization in inflammatory bowel disease (IBD) patients is unknown. The aim of this study was to determine hospital outcomes of CMV-related hospitalization in IBD patients in a large national inpatient administrative data set. METHODS: This was a cross-sectional study using data from the Nationwide In-patient Sample database. IBD-and CMV-related hospitalizations between 2003 and 2011 were identified using appropriate ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) codes. Impact of CMV-related hospitalization on in-hospital mortality, length of stay (LOS), and hospital charges were quantified. RESULTS: CMV-related hospitalization was associated with higher in-hospital mortality (odds ratio (OR) 7.09, 95% confidence interval (CI) 3.38 14.85), prolonged LOS (7.77 days, Po0.0001), and more hospital charge (US$66,495, Po0.0001) in IBD patients. CONCLUSIONS: CMV-related hospitalization in IBD is associated with high in-hospital mortality, prolonged LOS, and hospital care costs.