TY - JOUR
T1 - DARPP-32 binds to tra2-beta1 and influences alternative splicing
AU - Benderska, Natalya
AU - Becker, Kristina
AU - Girault, Jean Antoine
AU - Becker, Cord Michael
AU - Andreadis, Athena
AU - Stamm, Stefan
PY - 2010
Y1 - 2010
N2 - The majority of human genes undergo alternative splicing, which is frequently altered in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein, 32 kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32 binds directly to the splicing factor tra2- beta1 (transformer 2). DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing.
AB - The majority of human genes undergo alternative splicing, which is frequently altered in response to physiological stimuli. DARPP-32 (dopamine and cAMP regulated phosphoprotein, 32 kDa) is a component of PKA-dependent signaling pathways. Here we show that DARPP-32 binds directly to the splicing factor tra2- beta1 (transformer 2). DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing.
KW - Alternative splicing
KW - DARPP-32
KW - Protein phosphatase 1
KW - RNA processing
KW - Signaling
UR - https://www.scopus.com/pages/publications/77953693297
UR - https://www.scopus.com/pages/publications/77953693297#tab=citedBy
U2 - 10.1016/j.bbagrm.2010.01.003
DO - 10.1016/j.bbagrm.2010.01.003
M3 - Article
C2 - 20074680
AN - SCOPUS:77953693297
SN - 1874-9399
VL - 1799
SP - 448
EP - 453
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 5-6
ER -