Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Jason Cook; Sumathi Krishnan; Subbian Ananth; Stephen F. Sells; Yang Shi; McClellan M. Walther; W. Marston Linehan; Vikas P. Sukhatme; Michael H. Weinstein; Vivek M. Rangnekar

doi:10.1038/sj.onc.1202416

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Jason Cook
, Sumathi Krishnan
, Subbian Ananth
, Stephen F. Sells
, Yang Shi
, McClellan M. Walther
, W. Marston Linehan
, Vikas P. Sukhatme
, Michael H. Weinstein
, Vivek M. Rangnekar

Producción científica: Article › revisión exhaustiva

104 Citas (Scopus)

Resumen

Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

Idioma original	English
Páginas (desde-hasta)	1205-1208
Número de páginas	4
Publicación	Oncogene
Volumen	18
N.º	5
DOI	https://doi.org/10.1038/sj.onc.1202416
Estado	Published - feb 4 1999

Nota bibliográfica

Funding Information:
This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.

Financiación

This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.

Financiadores	Número del financiador
Council for Tobacco Research-USA	CA68258, 3490
National Institutes of Health (NIH)	CA60872
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK044921

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/sj.onc.1202416

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title = "Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma",

abstract = "Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.",

keywords = "Apoptosis, Par-4, Renal cell carcinoma",

author = "Jason Cook and Sumathi Krishnan and Subbian Ananth and Sells, \{Stephen F.\} and Yang Shi and Walther, \{McClellan M.\} and Linehan, \{W. Marston\} and Sukhatme, \{Vikas P.\} and Weinstein, \{Michael H.\} and Rangnekar, \{Vivek M.\}",

note = "Funding Information: This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.",

year = "1999",

month = feb,

day = "4",

doi = "10.1038/sj.onc.1202416",

language = "English",

volume = "18",

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T1 - Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

AU - Cook, Jason

AU - Krishnan, Sumathi

AU - Ananth, Subbian

AU - Sells, Stephen F.

AU - Shi, Yang

AU - Walther, McClellan M.

AU - Linehan, W. Marston

AU - Sukhatme, Vikas P.

AU - Weinstein, Michael H.

AU - Rangnekar, Vivek M.

N1 - Funding Information: This work was supported by NIH grant CA60872 and Council for Tobacco Research-USA grant 3490 to VMR: NIH grant CA68258 to YS; and NIH grant DK44921 to VPS.

PY - 1999/2/4

Y1 - 1999/2/4

N2 - Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

AB - Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.

KW - Apoptosis

KW - Par-4

KW - Renal cell carcinoma

UR - https://www.scopus.com/pages/publications/0033521923

UR - https://www.scopus.com/pages/publications/0033521923#tab=citedBy

U2 - 10.1038/sj.onc.1202416

DO - 10.1038/sj.onc.1202416

M3 - Article

C2 - 10022126

AN - SCOPUS:0033521923

SN - 0950-9232

VL - 18

SP - 1205

EP - 1208

JO - Oncogene

JF - Oncogene

IS - 5

ER -

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

Acceder al documento

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