Degradation of target protein in living cells by small-molecule proteolysis inducer

Dong Zhang; Sun Hee Baek; Abby Ho; Kyungbo Kim

doi:10.1016/j.bmcl.2003.11.042

Degradation of target protein in living cells by small-molecule proteolysis inducer

Dong Zhang
, Sun Hee Baek
, Abby Ho
, Kyungbo Kim

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

67 Citas (Scopus)

Resumen

Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function posttranslationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI).

Idioma original	English
Páginas (desde-hasta)	645-648
Número de páginas	4
Publicación	Bioorganic and Medicinal Chemistry Letters
Volumen	14
N.º	3
DOI	https://doi.org/10.1016/j.bmcl.2003.11.042
Estado	Published - feb 9 2004

Nota bibliográfica

Funding Information:
We are grateful to the Division of Pharmaceutical Sciences (Univ. of Kentucky) for generous start-up fund and COBRE (NIH NCRR P20 RR15592) and the Kentucky Lung Cancer Research Program for financial support. We also thank Dr. Rohr for comments on the manuscript.

Financiación

We are grateful to the Division of Pharmaceutical Sciences (Univ. of Kentucky) for generous start-up fund and COBRE (NIH NCRR P20 RR15592) and the Kentucky Lung Cancer Research Program for financial support. We also thank Dr. Rohr for comments on the manuscript.

Financiadores	Número del financiador
Corporacion Nacional del Cobre
Pharmaceutical Sciences Division
Kentucky Lung Cancer Research Program
NIH/NCRR	P20 RR15592
National Center for Research Resources	P20RR015592

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2003.11.042

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abstract = "Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function posttranslationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI).",

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AU - Baek, Sun Hee

AU - Ho, Abby

AU - Kim, Kyungbo

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AB - Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function posttranslationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI).

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Degradation of target protein in living cells by small-molecule proteolysis inducer

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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