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Delayed elevation of platelet activating factor in ischemic hippocampus

  • L. Creed Pettigrew
  • , Jerome J. Meyer
  • , Susan D. Craddock
  • , Steven M. Butler
  • , Hsin Hsiung Tai
  • , Robert A. Yokel

Producción científica: Articlerevisión exhaustiva

16 Citas (Scopus)

Resumen

We used in vivo microdialysis to define the chronological relationship between release of thromboxane and platelet activating factor (PAF) into the extracellular space of ischemic hippocampus. The thromboxane level peaked after 20 min of postischemic reperfusion, followed by a delayed PAF response 120 min later. We conclude that cerebral ischemia causes delayed elevation of PAF in the extracellular space, long after the immediate synthesis and release of thromboxane metabolites.

Idioma originalEnglish
Páginas (desde-hasta)243-247
Número de páginas5
PublicaciónBrain Research
Volumen691
N.º1-2
DOI
EstadoPublished - sept 11 1995

Financiación

FinanciadoresNúmero del financiador
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke CouncilK08NS001505
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council

    ASJC Scopus subject areas

    • General Neuroscience
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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