Dendrophen, a novel glycyrrhetyl amino acid from Dendronephthya hemprichi

Mohamed Shaaban; Khaled A. Shaaban; Howaida I. Abd-Alla; Atef G. Hanna; Hartmut Laatsch

doi:10.1515/znb-2011-0413

Dendrophen, a novel glycyrrhetyl amino acid from Dendronephthya hemprichi

Mohamed Shaaban
, Khaled A. Shaaban
, Howaida I. Abd-Alla
, Atef G. Hanna
, Hartmut Laatsch

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

19 Citas (Scopus)

Resumen

Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.

Idioma original	English
Páginas (desde-hasta)	425-432
Número de páginas	8
Publicación	Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volumen	66
N.º	4
DOI	https://doi.org/10.1515/znb-2011-0413
Estado	Published - abr 2011

Nota bibliográfica

Funding Information:
The authors are deeply thankful to Dr. M. Abd-Elghany, Hurgada, for the identification of Dendronephthya himprichi, and Dr. M. S. Abdel-Aziz, Department of Microbial Chemistry, NRC, Cairo, for the determination of antimicrobial activities. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. We thank also Ms. F. Lissy for biological tests and Mr. A. Kohl for technical assistance. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a short-term grant.

Financiación

The authors are deeply thankful to Dr. M. Abd-Elghany, Hurgada, for the identification of Dendronephthya himprichi, and Dr. M. S. Abdel-Aziz, Department of Microbial Chemistry, NRC, Cairo, for the determination of antimicrobial activities. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. We thank also Ms. F. Lissy for biological tests and Mr. A. Kohl for technical assistance. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a short-term grant.

Financiadores
Deutscher Akademischer Austauschdienst France

ASJC Scopus subject areas

General Chemistry

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title = "Dendrophen, a novel glycyrrhetyl amino acid from Dendronephthya hemprichi",

abstract = "Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.",

keywords = "Biological activity, Dendronephthya hemprichi, Dendrophen, Dendrotriol",

author = "Mohamed Shaaban and Shaaban, \{Khaled A.\} and Abd-Alla, \{Howaida I.\} and Hanna, \{Atef G.\} and Hartmut Laatsch",

note = "Funding Information: The authors are deeply thankful to Dr. M. Abd-Elghany, Hurgada, for the identification of Dendronephthya himprichi, and Dr. M. S. Abdel-Aziz, Department of Microbial Chemistry, NRC, Cairo, for the determination of antimicrobial activities. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. We thank also Ms. F. Lissy for biological tests and Mr. A. Kohl for technical assistance. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a short-term grant.",

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doi = "10.1515/znb-2011-0413",

language = "English",

volume = "66",

pages = "425--432",

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AU - Shaaban, Mohamed

AU - Shaaban, Khaled A.

AU - Abd-Alla, Howaida I.

AU - Hanna, Atef G.

AU - Laatsch, Hartmut

N1 - Funding Information: The authors are deeply thankful to Dr. M. Abd-Elghany, Hurgada, for the identification of Dendronephthya himprichi, and Dr. M. S. Abdel-Aziz, Department of Microbial Chemistry, NRC, Cairo, for the determination of antimicrobial activities. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. We thank also Ms. F. Lissy for biological tests and Mr. A. Kohl for technical assistance. M. Shaaban thanks the German Academic Exchange Service (DAAD) for a short-term grant.

PY - 2011/4

Y1 - 2011/4

N2 - Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.

AB - Chemical investigation of the extract of Dendronephthya hemprichi, collected from the Red Sea, Egypt, delivered dendrophen (1), the first 3β-acetoxy-glycyrrhetyl amino acid conjugate obtained from nature. Additionally, a new polyhydroxy sterol, dendrotriol (2), together with cholesterol and hexitol were isolated. Chromatographic separation of the low-polarity components of the D. hemprichi extract afforded 4-oxo-pentanoic acid, 2-methyl-acrylic acid 2-diethylaminoethyl ester (3), juniper camphor (4), and 2-octadecanone. The structures of 1 and 2 were confirmed by 1D and 2D NMR studies and mass spectrometry.

KW - Biological activity

KW - Dendronephthya hemprichi

KW - Dendrophen

KW - Dendrotriol

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U2 - 10.1515/znb-2011-0413

DO - 10.1515/znb-2011-0413

M3 - Article

AN - SCOPUS:79955011076

SN - 0932-0776

VL - 66

SP - 425

EP - 432

JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

JF - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

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Dendrophen, a novel glycyrrhetyl amino acid from Dendronephthya hemprichi

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