Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators

Fuying Li; Qingzhang Zhu; Yi Zhang; Ying Feng; Ying Leng; Ao Zhang

doi:10.1016/j.bmc.2010.04.038

Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators

Fuying Li
, Qingzhang Zhu
, Yi Zhang
, Ying Feng
, Ying Leng
, Ao Zhang

Producción científica: Article › revisión exhaustiva

Idioma original	English
Páginas (desde-hasta)	3875-3884
Número de páginas	10
Publicación	Bioorganic and Medicinal Chemistry
Volumen	18
N.º	11
DOI	https://doi.org/10.1016/j.bmc.2010.04.038
Estado	Published - jun 1 2010

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title = "Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators",

keywords = "Aminothiazole, Arylacetamide, Glucokinase activator, Type 2 diabetes (T2D)",

author = "Fuying Li and Qingzhang Zhu and Yi Zhang and Ying Feng and Ying Leng and Ao Zhang",

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Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators. / Li, Fuying; Zhu, Qingzhang; Zhang, Yi et al.
En: Bioorganic and Medicinal Chemistry, Vol. 18, N.º 11, 01.06.2010, p. 3875-3884.

Producción científica: Article › revisión exhaustiva

TY - JOUR

T1 - Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators

AU - Li, Fuying

AU - Zhu, Qingzhang

AU - Zhang, Yi

AU - Feng, Ying

AU - Leng, Ying

AU - Zhang, Ao

PY - 2010/6/1

Y1 - 2010/6/1

KW - Aminothiazole

KW - Arylacetamide

KW - Glucokinase activator

KW - Type 2 diabetes (T2D)

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Design, synthesis, and pharmacological evaluation of <i>N</i>-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2<i>H</i>-pyran-4-yl) propanamides as glucokinase activators

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