Dietary flavonoids as cancer prevention agents

Hua Yao; Weizheng Xu; Xianglin Shi; Zhuo Zhang

doi:10.1080/10590501.2011.551317

Dietary flavonoids as cancer prevention agents

Hua Yao, Weizheng Xu, Xianglin Shi, Zhuo Zhang

Toxicology and Cancer Biology

Producción científica: Article › revisión exhaustiva

105 Citas (Scopus)

Resumen

Dietary agents identified from fruits and vegetables contribute to keeping balanced cell proliferation and preventing cell carcinogenesis. Dietary flavonoids, combined with other components such as various vitamins, play an important role in cancer prevention. Flavonoids act on reactive oxygen species, cell signal transduction pathways related to cellular proliferation, apoptosis, and angiogenesis. Many studies demonstrate that flavonoids are responsible for chemoprevention, although mechanisms of action remain to be investigated. Overall, exciting data show that dietary flavonoids could be considered as a useful cancer preventive approach. This review summarizes recent advancements on potential cancer preventive effects and mechanic insight of dietary flavonoids.

Idioma original	English
Páginas (desde-hasta)	1-31
Número de páginas	31
Publicación	Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volumen	29
N.º	1
DOI	https://doi.org/10.1080/10590501.2011.551317
Estado	Published - ene 2011

Nota bibliográfica

Funding Information:
This work was supported by the International Science and Technology Cooperation Program of Zhejiang Province, China (grant no. 2010C34008) by Zhejiang Provincial Natural Science Foundation of China (Grant No. Y2100343), and by US National Institutes of Health (grant no. R01ES015375-02).

Financiación

This work was supported by the International Science and Technology Cooperation Program of Zhejiang Province, China (grant no. 2010C34008) by Zhejiang Provincial Natural Science Foundation of China (Grant No. Y2100343), and by US National Institutes of Health (grant no. R01ES015375-02).

Financiadores	Número del financiador
International Science and Technology Cooperation Program of Zhejiang Province	2010C34008
Zhejiang Provincial Natural Science Foundation of China	Y2100343
National Institutes of Health (NIH)

ASJC Scopus subject areas

Health, Toxicology and Mutagenesis
Cancer Research

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title = "Dietary flavonoids as cancer prevention agents",

abstract = "Dietary agents identified from fruits and vegetables contribute to keeping balanced cell proliferation and preventing cell carcinogenesis. Dietary flavonoids, combined with other components such as various vitamins, play an important role in cancer prevention. Flavonoids act on reactive oxygen species, cell signal transduction pathways related to cellular proliferation, apoptosis, and angiogenesis. Many studies demonstrate that flavonoids are responsible for chemoprevention, although mechanisms of action remain to be investigated. Overall, exciting data show that dietary flavonoids could be considered as a useful cancer preventive approach. This review summarizes recent advancements on potential cancer preventive effects and mechanic insight of dietary flavonoids.",

keywords = "EGCG, Naturally occurring cancer prevention agents, angiogenesis, antioxidant, apoptosis, cell cycle arrest, curcumin, dietary flavonoids, isothiocyanates, mechanistic insight, molecular targeting approach, oxidative stress, signal transduction pathways",

author = "Hua Yao and Weizheng Xu and Xianglin Shi and Zhuo Zhang",

note = "Funding Information: This work was supported by the International Science and Technology Cooperation Program of Zhejiang Province, China (grant no. 2010C34008) by Zhejiang Provincial Natural Science Foundation of China (Grant No. Y2100343), and by US National Institutes of Health (grant no. R01ES015375-02).",

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AU - Shi, Xianglin

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N2 - Dietary agents identified from fruits and vegetables contribute to keeping balanced cell proliferation and preventing cell carcinogenesis. Dietary flavonoids, combined with other components such as various vitamins, play an important role in cancer prevention. Flavonoids act on reactive oxygen species, cell signal transduction pathways related to cellular proliferation, apoptosis, and angiogenesis. Many studies demonstrate that flavonoids are responsible for chemoprevention, although mechanisms of action remain to be investigated. Overall, exciting data show that dietary flavonoids could be considered as a useful cancer preventive approach. This review summarizes recent advancements on potential cancer preventive effects and mechanic insight of dietary flavonoids.

AB - Dietary agents identified from fruits and vegetables contribute to keeping balanced cell proliferation and preventing cell carcinogenesis. Dietary flavonoids, combined with other components such as various vitamins, play an important role in cancer prevention. Flavonoids act on reactive oxygen species, cell signal transduction pathways related to cellular proliferation, apoptosis, and angiogenesis. Many studies demonstrate that flavonoids are responsible for chemoprevention, although mechanisms of action remain to be investigated. Overall, exciting data show that dietary flavonoids could be considered as a useful cancer preventive approach. This review summarizes recent advancements on potential cancer preventive effects and mechanic insight of dietary flavonoids.

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KW - molecular targeting approach

KW - oxidative stress

KW - signal transduction pathways

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Dietary flavonoids as cancer prevention agents

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

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