TY - JOUR
T1 - Differences in albuminuria between Hispanics and whites
T2 - An evaluation by genetic ancestry and country of origin: The multi-ethnic study of atherosclerosis
AU - Peralta, Carmen A.
AU - Li, Yongmei
AU - Wassel, Christina
AU - Choudhry, Shweta
AU - Palmas, Walter
AU - Seldin, Michael F.
AU - Risch, Neil
AU - Siscovick, David
AU - Arnett, Donna
AU - Psaty, Bruce
AU - Shlipak, Michael G.
PY - 2010/6
Y1 - 2010/6
N2 - Background-Reports show higher prevalence of albuminuria among Hispanics compared with whites. Differences by country of origin or genetic background are unknown. Methods and Results-In Multi-Ethnic Study of Atherosclerosis, we studied the associations of both genetic ancestry and country of origin with albumin to creatinine ratio among 1417 Hispanic versus white participants using multivariable linear regression and back transforming beta coefficients into relative difference (%RD, 95% CI). Percentage European, Native American, and African ancestry components for Hispanics were estimated using genetic admixture analysis. The proportions of European, Native American, and African genetic ancestry differed significantly by country of origin (P<0.0001); Mexican/Central Americans had the highest Native American (41±13%), Puerto Ricans had the highest European (61±15%), and Dominicans had the highest African (39±21%) ancestry. Hispanic ethnicity was associated with higher albumin/creatinine ratio compared with whites, but the association varied with the country of origin (adjusted P interaction-0.04). Mexican/Central Americans and Dominicans had higher albumin/creatinine ratio ompared with whites after adjustment (RD 19%, 2% to 40% and RD 27%, 1% to 61%), but not Puerto Ricans (RD %, -12% to 34%). Higher Native American ancestry was associated with higher albuminuria after age and sex djustment among all Hispanics (RD 11%, 1% to 21%) but was attenuated after further adjustment. Higher European ancestry was independently associated with lower albumin/creatinine ratio among Puerto Ricans (-21%, -34% to -6%) but not among Mexican/Central Americans and Dominicans. Conclusions-Hispanics are a heterogeneous group with varying genetic ancestry. Risks of albuminuria differ across the country of origin groups. These differences may be due, in part, to differences in genetic ancestral components.
AB - Background-Reports show higher prevalence of albuminuria among Hispanics compared with whites. Differences by country of origin or genetic background are unknown. Methods and Results-In Multi-Ethnic Study of Atherosclerosis, we studied the associations of both genetic ancestry and country of origin with albumin to creatinine ratio among 1417 Hispanic versus white participants using multivariable linear regression and back transforming beta coefficients into relative difference (%RD, 95% CI). Percentage European, Native American, and African ancestry components for Hispanics were estimated using genetic admixture analysis. The proportions of European, Native American, and African genetic ancestry differed significantly by country of origin (P<0.0001); Mexican/Central Americans had the highest Native American (41±13%), Puerto Ricans had the highest European (61±15%), and Dominicans had the highest African (39±21%) ancestry. Hispanic ethnicity was associated with higher albumin/creatinine ratio compared with whites, but the association varied with the country of origin (adjusted P interaction-0.04). Mexican/Central Americans and Dominicans had higher albumin/creatinine ratio ompared with whites after adjustment (RD 19%, 2% to 40% and RD 27%, 1% to 61%), but not Puerto Ricans (RD %, -12% to 34%). Higher Native American ancestry was associated with higher albuminuria after age and sex djustment among all Hispanics (RD 11%, 1% to 21%) but was attenuated after further adjustment. Higher European ancestry was independently associated with lower albumin/creatinine ratio among Puerto Ricans (-21%, -34% to -6%) but not among Mexican/Central Americans and Dominicans. Conclusions-Hispanics are a heterogeneous group with varying genetic ancestry. Risks of albuminuria differ across the country of origin groups. These differences may be due, in part, to differences in genetic ancestral components.
KW - Albuminuria
KW - Ancestry
KW - Genetics
KW - Kidney
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U2 - 10.1161/CIRCGENETICS.109.914499
DO - 10.1161/CIRCGENETICS.109.914499
M3 - Article
C2 - 20445135
AN - SCOPUS:77955870187
SN - 1942-325X
VL - 3
SP - 240
EP - 247
JO - Circulation: Cardiovascular Genetics
JF - Circulation: Cardiovascular Genetics
IS - 3
ER -