Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains

Chengfeng Yang; Ying S. Tan; Jack R. Harkema; Sandra Z. Haslam

doi:10.1016/j.reprotox.2008.10.003

Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains

Chengfeng Yang
, Ying S. Tan
, Jack R. Harkema
, Sandra Z. Haslam

Markey Cancer Center / Cancer Research Priority Initiative

Producción científica: Article › revisión exhaustiva

78 Citas (Scopus)

Resumen

Perfluorooctanoic acid (PFOA), a common and persistent industrial byproduct detected in human sera, has raised health concerns. PFOA is detrimental to lactational function and postnatal mammary gland development in CD-1 mice after gestational exposure. We have examined the peripubertal period (21 through 50 days of age) as an important window of mammary gland susceptibility to environmental exposures that may affect breast cancer risk later in life. The effects of PFOA (0.1-10 mg/kg BW) were examined in Balb/c and C57BL/6 mice. PFOA treatment caused hepatocellular hypertrophy and delayed vaginal opening in both mouse strains. While Balb/c mice exhibited only inhibition of mammary gland and uterine development (5, 10 mg/kg), C57BL/6 mice exhibited stimulatory effects in both organs at low dose (5 mg/kg) and inhibition at higher dose (10 mg/kg). This underscores the need for caution when drawing conclusions about the effects of PFOA and possibly other environmental pollutants on the basis of studies in a single mouse strain.

Idioma original	English
Páginas (desde-hasta)	299-306
Número de páginas	8
Publicación	Reproductive Toxicology
Volumen	27
N.º	3-4
DOI	https://doi.org/10.1016/j.reprotox.2008.10.003
Estado	Published - jun 2009

Nota bibliográfica

Funding Information:
The authors thank Dr. Jianwei Xie for the statistical analyses. This work was supported by the Breast Cancer and the Environment Research Centers Grant 1-UO1 ES/CA012800 01from the National Institute of Environment Health Science (NIEHS) and the National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS or NCI, NIH.

Financiación

The authors thank Dr. Jianwei Xie for the statistical analyses. This work was supported by the Breast Cancer and the Environment Research Centers Grant 1-UO1 ES/CA012800 01from the National Institute of Environment Health Science (NIEHS) and the National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS or NCI, NIH.

Financiadores	Número del financiador
Breast Cancer Alliance Incorporated	1-UO1 ES/CA012800 01from
National Institute of Environment Health Science
National Institutes of Health (NIH)
U.S. Department of Health and Human Services
National Childhood Cancer Registry – National Cancer Institute
National Institute of Environmental Health Sciences (NIEHS)	U01ES012800

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Toxicology

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10.1016/j.reprotox.2008.10.003

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title = "Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains",

abstract = "Perfluorooctanoic acid (PFOA), a common and persistent industrial byproduct detected in human sera, has raised health concerns. PFOA is detrimental to lactational function and postnatal mammary gland development in CD-1 mice after gestational exposure. We have examined the peripubertal period (21 through 50 days of age) as an important window of mammary gland susceptibility to environmental exposures that may affect breast cancer risk later in life. The effects of PFOA (0.1-10 mg/kg BW) were examined in Balb/c and C57BL/6 mice. PFOA treatment caused hepatocellular hypertrophy and delayed vaginal opening in both mouse strains. While Balb/c mice exhibited only inhibition of mammary gland and uterine development (5, 10 mg/kg), C57BL/6 mice exhibited stimulatory effects in both organs at low dose (5 mg/kg) and inhibition at higher dose (10 mg/kg). This underscores the need for caution when drawing conclusions about the effects of PFOA and possibly other environmental pollutants on the basis of studies in a single mouse strain.",

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note = "Funding Information: The authors thank Dr. Jianwei Xie for the statistical analyses. This work was supported by the Breast Cancer and the Environment Research Centers Grant 1-UO1 ES/CA012800 01from the National Institute of Environment Health Science (NIEHS) and the National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS or NCI, NIH.",

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language = "English",

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Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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