Direct reprogramming of induced neural progenitors: A new promising strategy for AD treatment

Siqiang Lai; Min Zhang; Dongsheng Xu; Yiying Zhang; Lisha Qiu; Changhai Tian; Jialin Charlie Zheng

doi:10.1186/s40035-015-0028-y

Direct reprogramming of induced neural progenitors: A new promising strategy for AD treatment

Siqiang Lai
, Min Zhang
, Dongsheng Xu
, Yiying Zhang
, Lisha Qiu
, Changhai Tian
, Jialin Charlie Zheng

Producción científica: Review article › revisión exhaustiva

11 Citas (Scopus)

Resumen

Alzheimer's disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cognitive functions. Currently, although a variety of medications can relieve some of the symptoms, there is no cure for AD. Recent breakthroughs in the stem cell field provide promising strategies for AD treatment. Stem cells including embryonic stem cells (ESCs), neural stem cells (NSCs), mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs) are potentials for AD treatment. However, the limitation of cell sources, safety issues, and ethical issues restrict their applications in AD. Recently, the direct reprogramming of induced neural progenitor cells (iNPCs) has shed light on the treatment of AD. In this review, we will discuss the latest progress, challenges, and potential applications of direct reprogramming in AD treatment.

Idioma original	English
Número de artículo	7
Publicación	Translational Neurodegeneration
Volumen	4
N.º	1
DOI	https://doi.org/10.1186/s40035-015-0028-y
Estado	Published - abr 18 2015

Nota bibliográfica

Publisher Copyright:
© Lai et al.; licensee BioMed Central.

Financiación

This work was partly supported by research grants by National Basic Research Program of China (973 Program Grant No. 2014CB965001), National Natural Science Foundation of China (#81271419), Innovative Research Groups of the National Natural Science Foundation of China (#81221001), and Joint Research Fund for Overseas Chinese, Hong Kong and Macao Young Scientists of the National Natural Science Foundation of China (#81329002); National Institutes of Health: R01 NS 41858–01, R01 NS 061642–01, P20 RR15635-01, the State of Nebraska, DHHS-LB606 Stem Cell 2009–10 (JZ), LB606 Stem Cell-2010-10 (CT). Julie Ditter, Lenal Bottoms, Johna Belling, Jaclyn Ostronic and Robin Taylor provided outstanding administrative and secretarial support.

Financiadores	Número del financiador
Joint Research Fund for Overseas Chinese, Hong Kong and Macao Young Scientists	81329002
National Institutes of Health (NIH)	R01 NS 061642–01, P20 RR15635-01, R01 NS 41858–01, LB606 Stem Cell-2010-10
National Natural Science Foundation of China (NSFC)	81221001, 81271419
National Key Basic Research and Development Program of China	2014CB965001

ASJC Scopus subject areas

Clinical Neurology
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1186/s40035-015-0028-y

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title = "Direct reprogramming of induced neural progenitors: A new promising strategy for AD treatment",

abstract = "Alzheimer's disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cognitive functions. Currently, although a variety of medications can relieve some of the symptoms, there is no cure for AD. Recent breakthroughs in the stem cell field provide promising strategies for AD treatment. Stem cells including embryonic stem cells (ESCs), neural stem cells (NSCs), mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs) are potentials for AD treatment. However, the limitation of cell sources, safety issues, and ethical issues restrict their applications in AD. Recently, the direct reprogramming of induced neural progenitor cells (iNPCs) has shed light on the treatment of AD. In this review, we will discuss the latest progress, challenges, and potential applications of direct reprogramming in AD treatment.",

keywords = "Alzheimer's disease, Induced neural progenitor cells, Stem cell-based therapy",

author = "Siqiang Lai and Min Zhang and Dongsheng Xu and Yiying Zhang and Lisha Qiu and Changhai Tian and Zheng, \{Jialin Charlie\}",

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AU - Lai, Siqiang

AU - Zhang, Min

AU - Xu, Dongsheng

AU - Zhang, Yiying

AU - Qiu, Lisha

AU - Tian, Changhai

AU - Zheng, Jialin Charlie

PY - 2015/4/18

Y1 - 2015/4/18

N2 - Alzheimer's disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cognitive functions. Currently, although a variety of medications can relieve some of the symptoms, there is no cure for AD. Recent breakthroughs in the stem cell field provide promising strategies for AD treatment. Stem cells including embryonic stem cells (ESCs), neural stem cells (NSCs), mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs) are potentials for AD treatment. However, the limitation of cell sources, safety issues, and ethical issues restrict their applications in AD. Recently, the direct reprogramming of induced neural progenitor cells (iNPCs) has shed light on the treatment of AD. In this review, we will discuss the latest progress, challenges, and potential applications of direct reprogramming in AD treatment.

AB - Alzheimer's disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cognitive functions. Currently, although a variety of medications can relieve some of the symptoms, there is no cure for AD. Recent breakthroughs in the stem cell field provide promising strategies for AD treatment. Stem cells including embryonic stem cells (ESCs), neural stem cells (NSCs), mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs) are potentials for AD treatment. However, the limitation of cell sources, safety issues, and ethical issues restrict their applications in AD. Recently, the direct reprogramming of induced neural progenitor cells (iNPCs) has shed light on the treatment of AD. In this review, we will discuss the latest progress, challenges, and potential applications of direct reprogramming in AD treatment.

KW - Alzheimer's disease

KW - Induced neural progenitor cells

KW - Stem cell-based therapy

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Direct reprogramming of induced neural progenitors: A new promising strategy for AD treatment

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Nota bibliográfica

Financiación

ASJC Scopus subject areas

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