Diversifying vancomycin via chemoenzymatic strategies

Xun Fu; Christoph Albermann; Changsheng Zhang; Jon S. Thorson

doi:10.1021/ol0501626

Diversifying vancomycin via chemoenzymatic strategies

Xun Fu
, Christoph Albermann
, Changsheng Zhang
, Jon S. Thorson

Producción científica: Article › revisión exhaustiva

108 Citas (Scopus)

Resumen

(Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

Idioma original	English
Páginas (desde-hasta)	1513-1515
Número de páginas	3
Publicación	Organic Letters
Volumen	7
N.º	8
DOI	https://doi.org/10.1021/ol0501626
Estado	Published - abr 14 2005

Financiación

Financiadores	Número del financiador
National Institute of Allergy and Infectious Diseases	R01AI052218

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0501626

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title = "Diversifying vancomycin via chemoenzymatic strategies",

abstract = "(Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.",

author = "Xun Fu and Christoph Albermann and Changsheng Zhang and Thorson, \{Jon S.\}",

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T1 - Diversifying vancomycin via chemoenzymatic strategies

AU - Fu, Xun

AU - Albermann, Christoph

AU - Zhang, Changsheng

AU - Thorson, Jon S.

PY - 2005/4/14

Y1 - 2005/4/14

N2 - (Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

AB - (Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

UR - https://www.scopus.com/pages/publications/17844409813

UR - https://www.scopus.com/pages/publications/17844409813#tab=citedBy

U2 - 10.1021/ol0501626

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M3 - Article

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SN - 1523-7060

VL - 7

SP - 1513

EP - 1515

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Diversifying vancomycin via chemoenzymatic strategies

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ASJC Scopus subject areas

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