DNA-damage response in tissue-specific and cancer stem cells

Cedric Blanpain; Mary Mohrin; Panagiota A. Sotiropoulou; Emmanuelle Passegué

doi:10.1016/j.stem.2010.12.012

DNA-damage response in tissue-specific and cancer stem cells

Cedric Blanpain
, Mary Mohrin
, Panagiota A. Sotiropoulou
, Emmanuelle Passegué

Producción científica: Review article › revisión exhaustiva

307 Citas (Scopus)

Resumen

Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to address DNA damage, and describe how these mechanisms can impact SC genomic integrity by potentially promoting aging, tissue atrophy, and/or cancer development. Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy.

Idioma original	English
Páginas (desde-hasta)	16-29
Número de páginas	14
Publicación	Cell Stem Cell
Volumen	8
N.º	1
DOI	https://doi.org/10.1016/j.stem.2010.12.012
Estado	Published - ene 7 2011

Financiación

We thank Drs. E. Pietras and M. Warr for their insightful comments. C.B. and P.A.S are chercheur qualifié of the Fonds de la Recherche Scientifique (F.R.S.)/Fonds National de la Recherche Scientifique (FNRS). M.M. is supported by a CIRM predoctoral training grant. This work was supported by the program CIBLES of the Wallonia Region, a research grant from the Fondation Contre le Cancer and the fond Gaston Ithier, a starting grant of the European Research Council (ERC) and the EMBO Young Investigator Program to C.B., and a CIRM New Faculty Award and Rita Allen Scholar Award to E.P.

Financiadores
California Institute for Regenerative Medicine
European Molecular Biology Organization
H2020 European Research Council
Stichting Tegen Kanker

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2010.12.012

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DNA-damage response in tissue-specific and cancer stem cells

Resumen

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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