Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Howard P. Glauert; Julia A. Weeks

doi:10.1016/0378-4274(89)90055-6

Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Howard P. Glauert, Julia A. Weeks

Pharmacology and Nutritional Sciences

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

Idioma original	English
Páginas (desde-hasta)	283-287
Número de páginas	5
Publicación	Toxicology Letters
Volumen	48
N.º	3
DOI	https://doi.org/10.1016/0378-4274(89)90055-6
Estado	Published - sept 1989

Nota bibliográfica

Funding Information:
We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.

Financiación

We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.

Financiadores	Número del financiador
University of Kentucky Graduate School
American Institute for Cancer Research	87B45
Kentucky Agricultural Experiment Station	88-9-188

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(89)90055-6

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@article{6f1b581081304ba89baa07466df438d1,

title = "Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine",

abstract = "The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7\% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.",

keywords = "1,2-Dimethylhydrazine, Adenocarcinomas, Colon carcinogenesis, Fischer-344 rats",

author = "Glauert, \{Howard P.\} and Weeks, \{Julia A.\}",

note = "Funding Information: We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.",

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doi = "10.1016/0378-4274(89)90055-6",

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AU - Glauert, Howard P.

AU - Weeks, Julia A.

N1 - Funding Information: We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.

PY - 1989/9

Y1 - 1989/9

N2 - The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

AB - The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

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KW - Adenocarcinomas

KW - Colon carcinogenesis

KW - Fischer-344 rats

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Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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