Dysregulation of Cellular Signaling by HER2/neu in Breast Cancer

Binhua P. Zhou; Mien Chie Hung

doi:10.1053/j.seminoncol.2003.08.006

Dysregulation of Cellular Signaling by HER2/neu in Breast Cancer

Binhua P. Zhou
, Mien Chie Hung

Producción científica: Article › revisión exhaustiva

120 Citas (Scopus)

Resumen

Human epidermal growth factor receptor-2 (HER2/neu; erbB2) belongs to a family of four transmembrane receptor tyrosine kinases involved in signal transduction pathways that regulate cell growth and proliferation. Amplification or overexpression of HER2/neu occurs in about 30% of human breast and ovarian cancers and is associated with a poor clinical outcome, including short survival time and short time to relapse. Recent advances in our understanding of HER2/neu signaling pathways have greatly increased our knowledge of breast cancer tumorigenesis and have provided new targets for treating breast and ovarian tumors that overexpress HER2/neu. This review will focus on the signaling network mediated by HER2/neu in breast cancer and discuss our understanding of these pathways, which seem to be particularly important in mediating cell survival and growth under a wide variety of circumstances in breast cancer.

Idioma original	English
Páginas (desde-hasta)	38-48
Número de páginas	11
Publicación	Seminars in Oncology
Volumen	30
N.º	5 SUPPL. 16
DOI	https://doi.org/10.1053/j.seminoncol.2003.08.006
Estado	Published - oct 2003

Nota bibliográfica

Funding Information:
Supported by National Institutes of Health grant nos. CA 58880, CA 77858, and CA 78633; by a SPORE grant in ovarian cancer (CA 83639) (M.-C. H.); and by the Nellie Connally Breast Cancer Research Fund at The University of Texas M. D. Anderson Cancer Center (M.-C. H.).

Financiación

Supported by National Institutes of Health grant nos. CA 58880, CA 77858, and CA 78633; by a SPORE grant in ovarian cancer (CA 83639) (M.-C. H.); and by the Nellie Connally Breast Cancer Research Fund at The University of Texas M. D. Anderson Cancer Center (M.-C. H.).

Financiadores	Número del financiador
National Institutes of Health (NIH)	CA 78633, CA 77858, CA 58880
National Childhood Cancer Registry – National Cancer Institute	P50CA083639
University of Texas Anderson Cancer Center

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Hematology
Oncology

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10.1053/j.seminoncol.2003.08.006

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title = "Dysregulation of Cellular Signaling by HER2/neu in Breast Cancer",

abstract = "Human epidermal growth factor receptor-2 (HER2/neu; erbB2) belongs to a family of four transmembrane receptor tyrosine kinases involved in signal transduction pathways that regulate cell growth and proliferation. Amplification or overexpression of HER2/neu occurs in about 30\% of human breast and ovarian cancers and is associated with a poor clinical outcome, including short survival time and short time to relapse. Recent advances in our understanding of HER2/neu signaling pathways have greatly increased our knowledge of breast cancer tumorigenesis and have provided new targets for treating breast and ovarian tumors that overexpress HER2/neu. This review will focus on the signaling network mediated by HER2/neu in breast cancer and discuss our understanding of these pathways, which seem to be particularly important in mediating cell survival and growth under a wide variety of circumstances in breast cancer.",

author = "Zhou, \{Binhua P.\} and Hung, \{Mien Chie\}",

note = "Funding Information: Supported by National Institutes of Health grant nos. CA 58880, CA 77858, and CA 78633; by a SPORE grant in ovarian cancer (CA 83639) (M.-C. H.); and by the Nellie Connally Breast Cancer Research Fund at The University of Texas M. D. Anderson Cancer Center (M.-C. H.). ",

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AU - Hung, Mien Chie

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AB - Human epidermal growth factor receptor-2 (HER2/neu; erbB2) belongs to a family of four transmembrane receptor tyrosine kinases involved in signal transduction pathways that regulate cell growth and proliferation. Amplification or overexpression of HER2/neu occurs in about 30% of human breast and ovarian cancers and is associated with a poor clinical outcome, including short survival time and short time to relapse. Recent advances in our understanding of HER2/neu signaling pathways have greatly increased our knowledge of breast cancer tumorigenesis and have provided new targets for treating breast and ovarian tumors that overexpress HER2/neu. This review will focus on the signaling network mediated by HER2/neu in breast cancer and discuss our understanding of these pathways, which seem to be particularly important in mediating cell survival and growth under a wide variety of circumstances in breast cancer.

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Dysregulation of Cellular Signaling by HER2/neu in Breast Cancer

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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Huella

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