Early recurrent ischemic stroke: A case-control study

Background and Purpose: Data concerning potentially treatable risk factors for early recurrent stroke are limited. Therefore, we carried out a retrospective case-control study to identify factors predisposing to early re infarction. Summary of Review: We identified all patients admitted to Duke University Hospital or the Durham Veterans Administration Medical Center during 1 year having two documented ischemic strokes within 90 days (n = 12 of 273). Twelve randomly selected patients matched for age, sex, and race but having only a single stroke served as controls. There were no significant differences between the groups with respect to a variety of factors including the presence of hypertension, diabetes, a history of transient ischemic attack, a history of stroke, cerebral site of the index stroke, and subtype of the index stroke. A potential cardioembolic source was more frequently identified in the patients with early recurrent stroke (seven of the 12 case-control pairs were discordant for a potential cardioembolic source; McNemar’s χ²test, p≤0.02). Conclusions: Of the variables examined, the presence of a potential cardioembolic source was the single statistically significant factor associated with reinfarct ion within the first 90 days after ischemic stroke. The limitations and possible therapeutic implications of these results are discussed.