Effects of gonadal steroids on catecholamine levels in the brain of the oyster toadfish

Keith R. Pennypacker; Michael L. Fine; Jennifer K. Stewart

doi:10.1016/0304-3940(85)90020-5

Effects of gonadal steroids on catecholamine levels in the brain of the oyster toadfish

Keith R. Pennypacker
, Michael L. Fine
, Jennifer K. Stewart

Producción científica: Article › revisión exhaustiva

8 Citas (Scopus)

Resumen

We studied the effects of gonadol steroid implants on catecholamine levels in the brain of ovariectomized female toadfish (Opsanus tau L.). Control values for dopamine (DA), norepinephrine (NE) and epinephrine (EPI) in the brain were 2181 ± 226, 1112 ± 80 and 6.5 ± 2.02 ng/g, respectively. Compared to controls, 17β-estradiol decreased brain levels of DA to 547 ± 261, and dihydrotestosterone decreased DA to 444 ± 290 ng/g (P < 0.001). Furthermore, dihydrotestosterone increased brain levels of EPI to 15.0 ± 4.7 ng/g. The steroids had no effect on brain levels of NE. These results suggest a role for both androgens and estrogens in regulating brain levels of DA and EPI in toadfish.

Idioma original	English
Páginas (desde-hasta)	203-206
Número de páginas	4
Publicación	Neuroscience Letters
Volumen	55
N.º	2
DOI	https://doi.org/10.1016/0304-3940(85)90020-5
Estado	Published - abr 9 1985

Nota bibliográfica

Funding Information:
This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.

Financiación

This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.

Financiadores	Número del financiador
National Institutes of Health (NIH)	AM31882, MH389921
Virginia Commonwealth University

ASJC Scopus subject areas

General Neuroscience

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@article{2056a116ddc7410eb6d833b88195f535,

title = "Effects of gonadal steroids on catecholamine levels in the brain of the oyster toadfish",

abstract = "We studied the effects of gonadol steroid implants on catecholamine levels in the brain of ovariectomized female toadfish (Opsanus tau L.). Control values for dopamine (DA), norepinephrine (NE) and epinephrine (EPI) in the brain were 2181 ± 226, 1112 ± 80 and 6.5 ± 2.02 ng/g, respectively. Compared to controls, 17β-estradiol decreased brain levels of DA to 547 ± 261, and dihydrotestosterone decreased DA to 444 ± 290 ng/g (P < 0.001). Furthermore, dihydrotestosterone increased brain levels of EPI to 15.0 ± 4.7 ng/g. The steroids had no effect on brain levels of NE. These results suggest a role for both androgens and estrogens in regulating brain levels of DA and EPI in toadfish.",

keywords = "dihydrotestosterone, dopamine, epinephrine, estradiol, norepinephrine, testosterone, toadfish",

author = "Pennypacker, \{Keith R.\} and Fine, \{Michael L.\} and Stewart, \{Jennifer K.\}",

note = "Funding Information: This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.",

year = "1985",

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language = "English",

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AU - Pennypacker, Keith R.

AU - Fine, Michael L.

AU - Stewart, Jennifer K.

N1 - Funding Information: This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.

PY - 1985/4/9

Y1 - 1985/4/9

N2 - We studied the effects of gonadol steroid implants on catecholamine levels in the brain of ovariectomized female toadfish (Opsanus tau L.). Control values for dopamine (DA), norepinephrine (NE) and epinephrine (EPI) in the brain were 2181 ± 226, 1112 ± 80 and 6.5 ± 2.02 ng/g, respectively. Compared to controls, 17β-estradiol decreased brain levels of DA to 547 ± 261, and dihydrotestosterone decreased DA to 444 ± 290 ng/g (P < 0.001). Furthermore, dihydrotestosterone increased brain levels of EPI to 15.0 ± 4.7 ng/g. The steroids had no effect on brain levels of NE. These results suggest a role for both androgens and estrogens in regulating brain levels of DA and EPI in toadfish.

AB - We studied the effects of gonadol steroid implants on catecholamine levels in the brain of ovariectomized female toadfish (Opsanus tau L.). Control values for dopamine (DA), norepinephrine (NE) and epinephrine (EPI) in the brain were 2181 ± 226, 1112 ± 80 and 6.5 ± 2.02 ng/g, respectively. Compared to controls, 17β-estradiol decreased brain levels of DA to 547 ± 261, and dihydrotestosterone decreased DA to 444 ± 290 ng/g (P < 0.001). Furthermore, dihydrotestosterone increased brain levels of EPI to 15.0 ± 4.7 ng/g. The steroids had no effect on brain levels of NE. These results suggest a role for both androgens and estrogens in regulating brain levels of DA and EPI in toadfish.

KW - dihydrotestosterone

KW - dopamine

KW - epinephrine

KW - estradiol

KW - norepinephrine

KW - testosterone

KW - toadfish

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UR - https://www.scopus.com/pages/publications/0021954725#tab=citedBy

U2 - 10.1016/0304-3940(85)90020-5

DO - 10.1016/0304-3940(85)90020-5

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AN - SCOPUS:0021954725

SN - 0304-3940

VL - 55

SP - 203

EP - 206

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Effects of gonadal steroids on catecholamine levels in the brain of the oyster toadfish

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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Huella

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