Electron bifurcation

John W. Peters; Anne Frances Miller; Anne K. Jones; Paul W. King; Michael W.W. Adams

doi:10.1016/j.cbpa.2016.03.007

Electron bifurcation

John W. Peters, Anne Frances Miller, Anne K. Jones, Paul W. King, Michael W.W. Adams

Producción científica: Review article › revisión exhaustiva

123 Citas (Scopus)

Resumen

Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.

Idioma original	English
Páginas (desde-hasta)	146-152
Número de páginas	7
Publicación	Current Opinion in Chemical Biology
Volumen	31
DOI	https://doi.org/10.1016/j.cbpa.2016.03.007
Estado	Published - abr 1 2016

Nota bibliográfica

Publisher Copyright:
© 2016.

Financiación

This work is supported as part of the Biological and Electron Transfer and Catalysis (BETCy) EFRC, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science ( DE-SC0012518 ). P.W.K. was supported by the U.S. Department of Energy under contract no. DE-AC36-08-GO28308 with the National Renewable Energy Laboratory. We thank the entire BETCy team for helpful discussions.

Financiadores	Número del financiador
EFRC
U.S. Department of Energy EPSCoR
Office of Science Programs	DE-SC0012518

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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AU - Peters, John W.

AU - Miller, Anne Frances

AU - Jones, Anne K.

AU - King, Paul W.

AU - Adams, Michael W.W.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.

AB - Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.

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DO - 10.1016/j.cbpa.2016.03.007

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SP - 146

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JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

ER -

Electron bifurcation

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

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