Electron spin resonance investigations of membrane proteins in erythrocytes in muscle diseases. Duchenne and myotonic muscular dystrophy and congenital myotonia

Allan Butterfield

doi:10.1016/0005-2736(77)90056-6

Electron spin resonance investigations of membrane proteins in erythrocytes in muscle diseases. Duchenne and myotonic muscular dystrophy and congenital myotonia

Allan Butterfield

Producción científica: Article › revisión exhaustiva

57 Citas (Scopus)

Resumen

Comparison of electron spin resonance spectra of spin labeled erythrocyte membranes from patients with the dystrophic conditions Duchenne and myotonic muscular dystrophy with those of normal controls suggests that alterations in membrane protein conformation and/or organization are present in these disease states. These protein alterations are not apparent in the nondystrophic disease congenital myotonia. The results suggest a correlation between changes in the physical state of protein in membranes with the presence of dystrophy. In addition, the present results from erythrocytes lend support for the concept of a generalized membrane defect in these diseases.

Idioma original	English
Páginas (desde-hasta)	1-7
Número de páginas	7
Publicación	BBA - Biomembranes
Volumen	470
N.º	1
DOI	https://doi.org/10.1016/0005-2736(77)90056-6
Estado	Published - oct 3 1977

Nota bibliográfica

Funding Information:
The author wishes to thank Drs. William Markesbery and Robert Egel of the Department of Neurology for help in patientdiagnosis and Drs. Robert Lester and Roger Laine of the Department of Biochemistry for helpful discussions and for making some research facilities available. This work was supported in part by a research grant from the Muscular Dystrophy Association of America, Inc., a Frederick Gardner Cottrell Research Grant from the Research Corporation and funds from the Research Foundation and Graduate School of the University of Kentucky.

Financiación

The author wishes to thank Drs. William Markesbery and Robert Egel of the Department of Neurology for help in patientdiagnosis and Drs. Robert Lester and Roger Laine of the Department of Biochemistry for helpful discussions and for making some research facilities available. This work was supported in part by a research grant from the Muscular Dystrophy Association of America, Inc., a Frederick Gardner Cottrell Research Grant from the Research Corporation and funds from the Research Foundation and Graduate School of the University of Kentucky.

Financiadores
Graduate School of the University of Kentucky
Muscular Dystrophy Association of America, Inc.
Research Corporation for Science Advancement
ASCRS Research Foundation

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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10.1016/0005-2736(77)90056-6

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title = "Electron spin resonance investigations of membrane proteins in erythrocytes in muscle diseases. Duchenne and myotonic muscular dystrophy and congenital myotonia",

abstract = "Comparison of electron spin resonance spectra of spin labeled erythrocyte membranes from patients with the dystrophic conditions Duchenne and myotonic muscular dystrophy with those of normal controls suggests that alterations in membrane protein conformation and/or organization are present in these disease states. These protein alterations are not apparent in the nondystrophic disease congenital myotonia. The results suggest a correlation between changes in the physical state of protein in membranes with the presence of dystrophy. In addition, the present results from erythrocytes lend support for the concept of a generalized membrane defect in these diseases.",

author = "Allan Butterfield",

note = "Funding Information: The author wishes to thank Drs. William Markesbery and Robert Egel of the Department of Neurology for help in patientdiagnosis and Drs. Robert Lester and Roger Laine of the Department of Biochemistry for helpful discussions and for making some research facilities available. This work was supported in part by a research grant from the Muscular Dystrophy Association of America, Inc., a Frederick Gardner Cottrell Research Grant from the Research Corporation and funds from the Research Foundation and Graduate School of the University of Kentucky.",

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N1 - Funding Information: The author wishes to thank Drs. William Markesbery and Robert Egel of the Department of Neurology for help in patientdiagnosis and Drs. Robert Lester and Roger Laine of the Department of Biochemistry for helpful discussions and for making some research facilities available. This work was supported in part by a research grant from the Muscular Dystrophy Association of America, Inc., a Frederick Gardner Cottrell Research Grant from the Research Corporation and funds from the Research Foundation and Graduate School of the University of Kentucky.

PY - 1977/10/3

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N2 - Comparison of electron spin resonance spectra of spin labeled erythrocyte membranes from patients with the dystrophic conditions Duchenne and myotonic muscular dystrophy with those of normal controls suggests that alterations in membrane protein conformation and/or organization are present in these disease states. These protein alterations are not apparent in the nondystrophic disease congenital myotonia. The results suggest a correlation between changes in the physical state of protein in membranes with the presence of dystrophy. In addition, the present results from erythrocytes lend support for the concept of a generalized membrane defect in these diseases.

AB - Comparison of electron spin resonance spectra of spin labeled erythrocyte membranes from patients with the dystrophic conditions Duchenne and myotonic muscular dystrophy with those of normal controls suggests that alterations in membrane protein conformation and/or organization are present in these disease states. These protein alterations are not apparent in the nondystrophic disease congenital myotonia. The results suggest a correlation between changes in the physical state of protein in membranes with the presence of dystrophy. In addition, the present results from erythrocytes lend support for the concept of a generalized membrane defect in these diseases.

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Electron spin resonance investigations of membrane proteins in erythrocytes in muscle diseases. Duchenne and myotonic muscular dystrophy and congenital myotonia

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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