Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

M. A. Lovell; W. D. Ehmann; M. P. Mattson; W. R. Markesbery

doi:10.1016/S0197-4580(97)00108-5

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

M. A. Lovell
, W. D. Ehmann
, M. P. Mattson
, W. R. Markesbery

Producción científica: Article › revisión exhaustiva

386 Citas (Scopus)

Resumen

4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

Idioma original	English
Páginas (desde-hasta)	457-461
Número de páginas	5
Publicación	Neurobiology of Aging
Volumen	18
N.º	5
DOI	https://doi.org/10.1016/S0197-4580(97)00108-5
Estado	Published - sept 1997

Nota bibliográfica

Funding Information:
The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

Financiación

The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

Financiadores	Número del financiador
National Institutes of Health (NIH)	1-P01-AG05119
National Institute on Aging	P50AG005144
Abercrombie Foundation

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/S0197-4580(97)00108-5

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title = "Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease",

abstract = "4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.",

keywords = "4-Hydroxynonenal, Alzheimer's disease, Lipid peroxidation, Oxidative stress, Ventricular fluid",

author = "Lovell, \{M. A.\} and Ehmann, \{W. D.\} and Mattson, \{M. P.\} and Markesbery, \{W. R.\}",

note = "Funding Information: The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.",

year = "1997",

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doi = "10.1016/S0197-4580(97)00108-5",

language = "English",

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T1 - Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

AU - Lovell, M. A.

AU - Ehmann, W. D.

AU - Mattson, M. P.

AU - Markesbery, W. R.

N1 - Funding Information: The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

PY - 1997/9

Y1 - 1997/9

N2 - 4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

AB - 4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

KW - 4-Hydroxynonenal

KW - Alzheimer's disease

KW - Lipid peroxidation

KW - Oxidative stress

KW - Ventricular fluid

UR - https://www.scopus.com/pages/publications/0030714092

UR - https://www.scopus.com/pages/publications/0030714092#tab=citedBy

U2 - 10.1016/S0197-4580(97)00108-5

DO - 10.1016/S0197-4580(97)00108-5

M3 - Article

C2 - 9390770

AN - SCOPUS:0030714092

SN - 0197-4580

VL - 18

SP - 457

EP - 461

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 5

ER -

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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