@article{b70ea433438e4277bf03793afee5f524,
title = "Elevated oxidative stress in models of normal brain aging and Alzheimer's disease",
abstract = "Age-associated neurodegenerative disorders are becoming more prevalent as the mean age of the population increases in the United States over the next few decades. Both normal brain aging and Alzheimer's disease (AD) are associated with oxidative stress. Our laboratory has used a wide variety of physical and biochemical methods to investigate free radical oxidative stress in several models of aging and AD. β-Amyloid (Aβ), the peptide that constitutes the central core of senile plaques in AD brain, is associated with free radical oxidative stress and is toxic to neurons. This review summarizes some of our studies in aging and Aβ-associated free radical oxidative stress and on the modulating effects of free radical scavengers on neocortical synaptosomal membrane damage found in aging and Aβ-treated systems.",
keywords = "Aging, Alzheimer's disease, Free radicals, Hydroxynonenal, Lipid peroxidation, Protein oxidation, β-Amyloid",
author = "\{Allan Butterfield\}, D. and Beverly Howard and Servet Yatin and Tanuja Koppal and Jennifer Drake and Kenneth Hensley and Michael Aksenov and Marina Aksenova and Ram Subramaniam and Sridhar Varadarajan and Harris-White, \{Marni E.\} and Pedigo, \{Norman W.\} and Carney, \{John M.\}",
year = "1999",
month = oct,
day = "1",
doi = "10.1016/S0024-3205(99)00442-7",
language = "English",
volume = "65",
pages = "1883--1892",
number = "18-19",
}