Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory

Yu Zhao; Guigen Zhang

doi:10.1109/ISSPIT.2018.8705145

Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory

Yu Zhao
, Guigen Zhang

Biomedical Engineering

Producción científica: Conference contribution › revisión exhaustiva

2 Citas (Scopus)

Resumen

AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.

Idioma original	English
Título de la publicación alojada	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
ISBN (versión digital)	9781538675687
DOI	https://doi.org/10.1109/ISSPIT.2018.8705145
Estado	Published - jul 2 2018
Evento	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 - Louisville, United States Duración: dic 6 2018 → dic 8 2018

Serie de la publicación

Nombre	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Volumen	2019-January

Conference

Conference	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
País/Territorio	United States
Ciudad	Louisville
Período	12/6/18 → 12/8/18

Nota bibliográfica

Publisher Copyright:
© 2018 IEEE.

ASJC Scopus subject areas

Signal Processing
Computer Science Applications
Computer Networks and Communications

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10.1109/ISSPIT.2018.8705145

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Zhao, Y., & Zhang, G. (2018). Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory. En 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 Artículo 8705145 (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018; Vol. 2019-January). https://doi.org/10.1109/ISSPIT.2018.8705145

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title = "Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory",

abstract = "AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.",

keywords = "dielectrophoresis (DEP), microtubule, septin, tubulin, tumor treating fields (TTF)",

author = "Yu Zhao and Guigen Zhang",

note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 ; Conference date: 06-12-2018 Through 08-12-2018",

year = "2018",

month = jul,

day = "2",

doi = "10.1109/ISSPIT.2018.8705145",

language = "English",

series = "2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018",

booktitle = "2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018",

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Zhao, Y & Zhang, G 2018, Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory. En 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018., 8705145, 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018, vol. 2019-January, 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018, Louisville, United States, 12/6/18. https://doi.org/10.1109/ISSPIT.2018.8705145

Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory. / Zhao, Yu; Zhang, Guigen.
2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018. 2018. 8705145 (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018; Vol. 2019-January).

Producción científica: Conference contribution › revisión exhaustiva

TY - GEN

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AU - Zhao, Yu

AU - Zhang, Guigen

PY - 2018/7/2

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N2 - AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.

AB - AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.

KW - dielectrophoresis (DEP)

KW - microtubule

KW - septin

KW - tubulin

KW - tumor treating fields (TTF)

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Y2 - 6 December 2018 through 8 December 2018

ER -

Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory

Resumen

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ASJC Scopus subject areas

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