TY - JOUR
T1 - Elucidation of the glycosylation sequence of mithramycin biosynthesis
T2 - Isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII
AU - Nur-E-Alam, Mohammad
AU - Méndez, Carmen
AU - Salas, José A.
AU - Rohr, Jürgen
PY - 2005/4
Y1 - 2005/4
N2 - The last step at last. The isolation and structure elucidation of the novel premithramycin-type compound 3A-deolivosylpremithramycin B (1) allowed cross-feeding experiments with this compound to two glycosyltransferase-minus mutants of the mithramycin producer S. argillaceus; this has solved the sequence of the last glycosylation steps of mithramycin biosynthesis.
AB - The last step at last. The isolation and structure elucidation of the novel premithramycin-type compound 3A-deolivosylpremithramycin B (1) allowed cross-feeding experiments with this compound to two glycosyltransferase-minus mutants of the mithramycin producer S. argillaceus; this has solved the sequence of the last glycosylation steps of mithramycin biosynthesis.
KW - Biosynthesis
KW - Glycosylation
KW - Glycosyltransferases
KW - Mithramycin
UR - https://www.scopus.com/pages/publications/21044441008
UR - https://www.scopus.com/inward/citedby.url?scp=21044441008&partnerID=8YFLogxK
U2 - 10.1002/cbic.200400309
DO - 10.1002/cbic.200400309
M3 - Article
C2 - 15712316
AN - SCOPUS:21044441008
SN - 1439-4227
VL - 6
SP - 632
EP - 636
JO - ChemBioChem
JF - ChemBioChem
IS - 4
ER -