Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

Sohei Ito; Hong S. Lu; Alan Daugherty; Hisashi Sawada

doi:10.3390/genes13091618

Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

Sohei Ito
, Hong S. Lu
, Alan Daugherty
, Hisashi Sawada

Producción científica: Review article › revisión exhaustiva

8 Citas (Scopus)

Resumen

Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.

Idioma original	English
Número de artículo	1618
Publicación	Genes
Volumen	13
N.º	9
DOI	https://doi.org/10.3390/genes13091618
Estado	Published - sept 2022

Nota bibliográfica

Publisher Copyright:
© 2022 by the authors.

Financiación

The authors’ aortic aneurysm-related research work is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (R35HL155649) and the American Heart Association SFRN in Vascular Disease (18SFRN33900001). The content in this review is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
National Institutes of Health (NIH)	R35HL155649
National Heart, Lung, and Blood Institute (NHLBI)
American the American Heart Association	18SFRN33900001

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms",

abstract = "Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.",

keywords = "aneurysm, aorta, cardiac neural crest, second heart field, smooth muscle, thoracic aorta",

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AU - Ito, Sohei

AU - Lu, Hong S.

AU - Daugherty, Alan

AU - Sawada, Hisashi

PY - 2022/9

Y1 - 2022/9

N2 - Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.

AB - Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.

KW - aneurysm

KW - aorta

KW - cardiac neural crest

KW - second heart field

KW - smooth muscle

KW - thoracic aorta

UR - https://www.scopus.com/pages/publications/85138412306

UR - https://www.scopus.com/pages/publications/85138412306#tab=citedBy

U2 - 10.3390/genes13091618

DO - 10.3390/genes13091618

M3 - Review article

C2 - 36140786

AN - SCOPUS:85138412306

SN - 2073-4425

VL - 13

JO - Genes

JF - Genes

IS - 9

M1 - 1618

ER -

Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

Resumen

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