Resumen
Metastatic melanoma remains incurable for many due to its aggressive nature. Secreted cathepsins promote metastasis by cleaving matrix and activating pro-invasive proteases. We reported that ABL kinases induce cathepsin secretion and subsequent metastasis by activating ETS1, SP1, and RELA pathways, indicating that ABL inhibitors may serve as novel anti-cathepsin agents.
| Idioma original | English |
|---|---|
| Número de artículo | e1458016 |
| Publicación | Molecular and Cellular Oncology |
| Volumen | 5 |
| N.º | 4 |
| DOI | |
| Estado | Published - jul 4 2018 |
Nota bibliográfica
Publisher Copyright:© 2018, © 2018 Taylor & Francis Group, LLC.
Financiación
This work was supported by NIH grants R01CA116784 and R01CA166499, and by a Markey Cancer Foundation Women Strong Award to R.P. The Research Communications Office of the Markey and Center (P30CA177558) supported this work and contributed to the figure. HHS j NIH j National Cancer Institute (NCI), HHS j NIH j National Cancer Institute (NCI). This work was supported by NIH grants R01CA116784 and R01CA166499, and by a Markey Cancer Foundation Women Strong Award to R.P.
| Financiadores | Número del financiador |
|---|---|
| Markey Cancer Center Foundation | |
| Markey Cancer Center the Center for Pharmaceutical Research and Innovation | P30CA177558 |
| National Institutes of Health (NIH) | R01CA116784, R01CA166499 |
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
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Good health and well being
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research
Huella
Profundice en los temas de investigación de 'EnABLing Cathepsin-Driven Melanoma Metastasis'. En conjunto forman una huella única.Citar esto
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