Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex

David R. Worthen; D. Alex Gibson; Dennis T. Rogers; Aimee K. Bence; May Fu; John M. Littleton; Peter A. Crooks

doi:10.1016/S0006-8993(00)03201-7

Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex

David R. Worthen
, D. Alex Gibson
, Dennis T. Rogers
, Aimee K. Bence
, May Fu
, John M. Littleton
, Peter A. Crooks

Psychology

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

High-throughput ligand displacement screens of a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily displace [³H]spermidine and [³H]MK-801 from their respective binding sites in rat brain homogenate. These data, coupled with their potent inhibition of spermidine-potentiated [³H]MK-801 binding, suggest that certain endogenous indoles may act as ligands to one or more polyamine binding sites in the brain, including those on the N-methyl-D-aspartate receptor complex.

Idioma original	English
Páginas (desde-hasta)	343-346
Número de páginas	4
Publicación	Brain Research
Volumen	890
N.º	2
DOI	https://doi.org/10.1016/S0006-8993(00)03201-7
Estado	Published - feb 2 2001

Nota bibliográfica

Funding Information:
This investigation was supported by National Institutes of Health, National Research Service award DA07304 from the National Institute on Drug Abuse, American Foundation for Pharmaceutical Education Fellowships (A.K.B. and D.R.W.) and National Institute of Alcohol Abuse and Alcoholism Grant AA12600.

Financiación

This investigation was supported by National Institutes of Health, National Research Service award DA07304 from the National Institute on Drug Abuse, American Foundation for Pharmaceutical Education Fellowships (A.K.B. and D.R.W.) and National Institute of Alcohol Abuse and Alcoholism Grant AA12600.

Financiadores	Número del financiador
National Institutes of Health (NIH)
Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse	R01DA007304
Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse
National Institute on Alcohol Abuse and Alcoholism	AA12600
National Institute on Alcohol Abuse and Alcoholism
American Foundation for Pharmaceutical Education

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Acceder al documento

10.1016/S0006-8993(00)03201-7

Otros archivos y enlaces

Citar esto

@article{454b072bbf0e4a8e97ee1b75da5db26f,

title = "Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex",

abstract = "High-throughput ligand displacement screens of a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily displace [3H]spermidine and [3H]MK-801 from their respective binding sites in rat brain homogenate. These data, coupled with their potent inhibition of spermidine-potentiated [3H]MK-801 binding, suggest that certain endogenous indoles may act as ligands to one or more polyamine binding sites in the brain, including those on the N-methyl-D-aspartate receptor complex.",

keywords = "CNS, Endogenous indole, N-Methyl-D-aspartate, Neuroprotection, Polyamine recognition domain",

author = "Worthen, \{David R.\} and Gibson, \{D. Alex\} and Rogers, \{Dennis T.\} and Bence, \{Aimee K.\} and May Fu and Littleton, \{John M.\} and Crooks, \{Peter A.\}",

note = "Funding Information: This investigation was supported by National Institutes of Health, National Research Service award DA07304 from the National Institute on Drug Abuse, American Foundation for Pharmaceutical Education Fellowships (A.K.B. and D.R.W.) and National Institute of Alcohol Abuse and Alcoholism Grant AA12600.",

year = "2001",

month = feb,

day = "2",

doi = "10.1016/S0006-8993(00)03201-7",

language = "English",

volume = "890",

pages = "343--346",

number = "2",

}

TY - JOUR

T1 - Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex

AU - Worthen, David R.

AU - Gibson, D. Alex

AU - Rogers, Dennis T.

AU - Bence, Aimee K.

AU - Fu, May

AU - Littleton, John M.

AU - Crooks, Peter A.

N1 - Funding Information: This investigation was supported by National Institutes of Health, National Research Service award DA07304 from the National Institute on Drug Abuse, American Foundation for Pharmaceutical Education Fellowships (A.K.B. and D.R.W.) and National Institute of Alcohol Abuse and Alcoholism Grant AA12600.

PY - 2001/2/2

Y1 - 2001/2/2

N2 - High-throughput ligand displacement screens of a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily displace [3H]spermidine and [3H]MK-801 from their respective binding sites in rat brain homogenate. These data, coupled with their potent inhibition of spermidine-potentiated [3H]MK-801 binding, suggest that certain endogenous indoles may act as ligands to one or more polyamine binding sites in the brain, including those on the N-methyl-D-aspartate receptor complex.

AB - High-throughput ligand displacement screens of a series of endogenous indoles revealed that tryptamine, serotonin and 5-methoxytryptamine readily displace [3H]spermidine and [3H]MK-801 from their respective binding sites in rat brain homogenate. These data, coupled with their potent inhibition of spermidine-potentiated [3H]MK-801 binding, suggest that certain endogenous indoles may act as ligands to one or more polyamine binding sites in the brain, including those on the N-methyl-D-aspartate receptor complex.

KW - CNS

KW - Endogenous indole

KW - N-Methyl-D-aspartate

KW - Neuroprotection

KW - Polyamine recognition domain

UR - https://www.scopus.com/pages/publications/0035793446

UR - https://www.scopus.com/pages/publications/0035793446#tab=citedBy

U2 - 10.1016/S0006-8993(00)03201-7

DO - 10.1016/S0006-8993(00)03201-7

M3 - Article

C2 - 11164802

AN - SCOPUS:0035793446

SN - 0006-8993

VL - 890

SP - 343

EP - 346

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto